Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.60 |
| ▸ | HTR1A | P08908 | 5/20 | 0.60 |
| ▸ | HTR1B | P28222 | 3/20 | 0.60 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.60 |
| ▸ | HTR1D | P28221 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.60 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | IDO1 | P14902 | 3/20 | 0.56 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.52 |
| ▸ | TUBB | P07437 | 3/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4632750 | 0.91 | HTR2A (0.60) | HTR2AHTR1AHTR1BTRPM8HTR1D | |
| SCHEMBL1399411 | 0.88 | MPO (0.65) | HTR2AHTR1ATRPM8TSHRIDO1 | |
| SCHEMBL1399238 | 0.87 | HTR2A (0.60) | HTR2AHTR1AHTR1BTRPM8HTR1D | |
| SCHEMBL4632929 | 0.86 | IDO1 (0.55) | HTR2AHTR1AHTR1BTRPM8HTR1D | |
| SCHEMBL1399200 | 0.85 | HTR1A (0.64) | HTR2AHTR1AHTR1BTRPM8HTR1D | |
| SCHEMBL1399440 | 0.85 | HTR2A (0.58) | HTR2AHTR1ATRPM8HTR1DIDO1 | |
| SCHEMBL1399264 | 0.84 | IDO1 (0.56) | HTR2AHTR1AMAPTHTR4IDO1 | |
| SCHEMBL1399398 | 0.83 | HTR2A (0.58) | HTR2AHTR1ATRPM8IDO1TUBB4A | |
| SCHEMBL1399448 | 0.83 | HTR2A (0.58) | HTR2AHTR1ATRPM8IDO1TUBB4A | |
| SCHEMBL4632232 | 0.81 | HTR2A (0.65) | HTR2AHTR1ATRPM8HTR2CIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1860100-B1 | 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRI | LUNDBECK & CO AS H (DK) | 2011-03-02 | — | — | EP | claimed |