Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 1/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPR3 | P17342 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14211341 | 0.87 | GRN (0.44) | GRNSORT1MAPK1KMT2AMAPT | |
| SCHEMBL14533530 | 0.87 | GRN (0.44) | GRNSORT1MAPK1KMT2AMAPT | |
| SCHEMBL22262968 | 0.81 | MAPK1 (0.38) | GRNSORT1MAPK1TDP1POLB | |
| SCHEMBL10209050 | 0.81 | CTSK (0.41) | TDP1POLBNPSR1ITGA4ITGB7 | |
| SCHEMBL8284484 | 0.81 | TDP1 (0.37) | TDP1POLBNPSR1ITGA4ITGB7 | |
| SCHEMBL25455581 | 0.80 | MAPK1 (0.36) | GRNSORT1MAPK1TDP1POLB | |
| SCHEMBL25453637 | 0.80 | MAPK1 (0.41) | GRNSORT1MAPK1TDP1POLB | |
| SCHEMBL23051973 | 0.80 | GRN (0.39) | GRNSORT1MAPK1TDP1POLB | |
| SCHEMBL17291698 | 0.79 | CTSK (0.36) | GRNSORT1MAPK1TDP1POLB | |
| SCHEMBL17219707 | 0.79 | GRN (0.35) | GRNSORT1MAPK1TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462637-B2 | Derivatives of [6,7-dihydro-5H-imidazo[1,2--a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-12-09 | — | — | US | disclosed |