Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 6/20 | 0.33 |
| ▸ | CTSS | P25774 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13993198 | 0.79 | GRN (0.43) | GRNSORT1MAPK1CTSKPOLB | |
| SCHEMBL22262968 | 0.79 | MAPK1 (0.38) | GRNSORT1MAPK1CTSKCTSS | |
| SCHEMBL23051973 | 0.77 | GRN (0.39) | GRNSORT1MAPK1CTSKCTSS | |
| SCHEMBL25455581 | 0.77 | MAPK1 (0.36) | GRNSORT1MAPK1CTSKCTSS | |
| SCHEMBL25453637 | 0.77 | MAPK1 (0.41) | GRNSORT1MAPK1CTSKCTSS | |
| SCHEMBL29750396 | 0.76 | CAD (0.39) | GRNSORT1MAPK1CTSKCTSS | |
| SCHEMBL17291698 | 0.76 | CTSK (0.36) | GRNSORT1MAPK1CTSKPOLB | |
| SCHEMBL23051981 | 0.75 | GRN (0.40) | GRNSORT1MAPK1CTSKCTSS | |
| SCHEMBL23051872 | 0.75 | CTSK (0.38) | GRNSORT1MAPK1CTSKCTSS | |
| SCHEMBL6007507 | 0.74 | CA12 (0.40) | CTSKCTSSNPSR1TDP1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150344404-A1 | PDK4 INHIBITOR AND USE THEREOF | THE KITASATO INSTITUTE (JP) | 2015-12-03 | — | — | US | disclosed |
| EP-2939668-A1 | PDK4 INHIBITOR AND USE THEREOF | The Kitasato Institute (JP) | 2015-11-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344404-A1 | PDK4 INHIBITOR AND USE THEREOF | PDK4, PDK3, PDK2 | GRN 3532/4885SORT1 4879/4885MAPK1 584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.