Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LATS1 | O95835 | 1/20 | 0.39 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13996670 | 0.84 | L3MBTL1 (0.51) | L3MBTL1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL25683002 | 0.80 | L3MBTL1 (0.61) | L3MBTL1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL29769140 | 0.75 | CHEK1 (0.58) | L3MBTL1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL8404434 | 0.75 | CHEK1 (0.58) | L3MBTL1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL18167974 | 0.75 | L3MBTL1 (0.68) | L3MBTL1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL16845708 | 0.73 | L3MBTL1 (0.57) | L3MBTL1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL13950560 | 0.72 | ALDH1A1 (0.57) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL12233426 | 0.72 | ROCK2 (0.58) | L3MBTL1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL13219425 | 0.72 | L3MBTL1 (1.00) | L3MBTL1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL21024680 | 0.69 | TRPA1 (0.46) | L3MBTL1MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465726-B2 | Substituted pyrrolo[2.3-B]pyridines | OSI PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |