Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP1 | Q9NZ08 | 5/20 | 0.51 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.51 |
| ▸ | IL1RN | P18510 | 2/20 | 0.51 |
| ▸ | ANPEP | P15144 | 3/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.46 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9408790 | 1.00 | ERAP1 (0.51) | ERAP1ERAP2IL1RNANPEPEPHX1 | |
| SCHEMBL9367442 | 0.88 | SLC6A2 (0.52) | ERAP1ERAP2ANPEPEPHX1SLC6A2 | |
| SCHEMBL4895850 | 0.83 | EPHX1 (0.56) | ERAP1ERAP2ANPEPEPHX1SLC6A2 | |
| SCHEMBL12193965 | 0.81 | EPHX1 (0.70) | ANPEPEPHX1SLC6A2TAAR1MAOA | |
| SCHEMBL11769571 | 0.81 | EPHX1 (0.70) | ERAP1ERAP2ANPEPEPHX1SLC6A2 | |
| SCHEMBL13995055 | 0.81 | EPHX1 (0.70) | ANPEPEPHX1SLC6A2TAAR1MAOA | |
| SCHEMBL170713 | 0.81 | EPHX1 (0.70) | ANPEPEPHX1SLC6A2TAAR1MAOA | |
| SCHEMBL13452965 | 0.79 | ANPEP (0.48) | ERAP1ERAP2ANPEPEPHX1SLC6A2 | |
| SCHEMBL1148969 | 0.79 | ANPEP (0.48) | ERAP1ERAP2ANPEPEPHX1SLC6A2 | |
| SCHEMBL4323451 | 0.79 | ANPEP (0.48) | ERAP1ERAP2ANPEPEPHX1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462625-B2 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-12-09 | — | — | US | disclosed |
| US-20070208049-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2007-09-06 | — | — | US | disclosed |
| US-7179815-B2 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179815-B2 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2007-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208049-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | GNRHR, GHRHR, LHCGR | ERAP1 1384/4885ERAP2 1380/4885IL1RN 470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.