Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.51 |
| ▸ | CHUK | O15111 | 2/20 | 0.42 |
| ▸ | INSR | P06213 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 5/20 | 0.42 |
| ▸ | AURKA | O14965 | 4/20 | 0.42 |
| ▸ | FLT3 | P36888 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | TEC | P42680 | 1/20 | 0.39 |
| ▸ | TXK | P42681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1399854 | 0.93 | MAPK14 (0.51) | MAPK14ALDH1A1KDRAURKAFLT3 | |
| SCHEMBL1399946 | 0.86 | MAPK14 (0.49) | MAPK14ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL3341342 | 0.86 | MAPK14 (0.63) | MAPK14 | |
| SCHEMBL1399881 | 0.86 | MAPK14 (0.48) | MAPK14ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL1399801 | 0.86 | MAPK14 (0.46) | MAPK14CHUKINSRMAPK8CAMKK2 | |
| SCHEMBL1399861 | 0.84 | ALDH1A1 (0.48) | MAPK14CHUKINSRMAPK8CAMKK2 | |
| SCHEMBL1399943 | 0.84 | MAPK14 (0.53) | MAPK14KDR | |
| SCHEMBL3341778 | 0.82 | MAPK14 (0.68) | MAPK14ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL1399827 | 0.82 | MAPK14 (0.53) | MAPK14 | |
| SCHEMBL3340960 | 0.82 | MAPK14 (0.67) | MAPK14ALDH1A1MEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831174-B1 | AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2011-03-02 | — | — | EP | claimed |
| US-7786115-B2 | Amide derivatives | ASTRAZENECA AB (SE) | 2010-08-31 | — | — | US | claimed |
| US-20080146566-A1 | Amide Derivatives | ASTRAZENECA AB (SE) | 2008-06-19 | — | — | US | claimed |
| EP-1831174-B1 | AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2011-03-02 | — | — | EP | disclosed |
| US-7786115-B2 | Amide derivatives | ASTRAZENECA AB (SE) | 2010-08-31 | — | — | US | disclosed |
| US-20080146566-A1 | Amide Derivatives | ASTRAZENECA AB (SE) | 2008-06-19 | — | — | US | disclosed |
| EP-1831174-A1 | AMIDE DERIVATIVES | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006067444-A1 | AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146566-A1 | Amide Derivatives | IL6, IL1B, IL1A | MAPK14 2077/4885CHUK 846/4885INSR 586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.