Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.45 |
| ▸ | MERTK | Q12866 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4708491 | 0.89 | HSD17B10 (0.47) | KDM4EALDH1A1AXLFLT3TYRO3 | |
| SCHEMBL14014470 | 0.88 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL14014888 | 0.88 | CAMKK2 (0.47) | KDM4EALDH1A1AXLFLT3TYRO3 | |
| SCHEMBL14014939 | 0.88 | KDM4E (0.48) | KDM4EALDH1A1KEAP1NFE2L2HPGD | |
| SCHEMBL14014960 | 0.88 | ALDH1A1 (0.42) | KDM4EALDH1A1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL14014880 | 0.88 | KEAP1 (0.46) | KDM4EALDH1A1AXLFLT3TYRO3 | |
| SCHEMBL6211737 | 0.87 | CAMKK2 (0.40) | KDM4EALDH1A1SMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL4710750 | 0.87 | KDM4E (0.52) | KDM4EALDH1A1AXLFLT3TYRO3 | |
| SCHEMBL14014941 | 0.86 | GCGR (0.45) | KDM4EALDH1A1CAMKK1CAMKK2ABL1 | |
| SCHEMBL4707198 | 0.86 | KDM4E (0.39) | KDM4EALDH1A1SMN1; SMN2KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |