Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | GRK6 | P43250 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14019804 | 0.83 | KIF11 (0.46) | KDM4ELMNAHTTNPSR1AR | |
| SCHEMBL14020242 | 0.80 | KIF11 (0.47) | KDM4EMEN1KMT2AGAAMAPT | |
| SCHEMBL14020082 | 0.80 | KIF11 (0.47) | KDM4EMEN1KMT2AGAAMAPT | |
| SCHEMBL23949921 | 0.78 | NR4A1 (0.41) | KDM4ELMNAHTTNPSR1AR | |
| SCHEMBL14020845 | 0.78 | KIF11 (0.51) | KDM4ELMNAHTTNPSR1AR | |
| SCHEMBL23949491 | 0.76 | MEN1 (0.42) | KDM4ELMNAHTTNPSR1AR | |
| SCHEMBL23949908 | 0.75 | DYRK2 (0.41) | KDM4ELMNAHTTNPSR1AR | |
| SCHEMBL23949460 | 0.75 | HNF4A (0.39) | KDM4ELMNAHTTNPSR1AR | |
| SCHEMBL23950051 | 0.73 | ESR1 (0.58) | KDM4ELMNAHTTNPSR1AR | |
| SCHEMBL14020880 | 0.69 | KIF11 (0.54) | KDM4ELMNAHTTNPSR1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2033959-A1 | Tetrahydropyranoquinoline derivatives | Merck Patent GmbH (DE) | 2009-03-11 | — | — | EP | disclosed |