Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 3/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14025094 | 0.81 | GSK3B (0.41) | KDM4EALDH1A1RORCMEN1KMT2A | |
| SCHEMBL15628442 | 0.80 | ALDH1A1 (0.46) | KDM4EALDH1A1PRMT5WDR77RORC | |
| SCHEMBL14024886 | 0.80 | ADRB1 (0.44) | KDM4EALDH1A1ADRB2ADRB1 | |
| SCHEMBL20026130 | 0.76 | ALDH1A1 (0.42) | KDM4EALDH1A1PRMT5WDR77RORC | |
| SCHEMBL14023963 | 0.75 | DPP4 (0.37) | RORCDPP4 | |
| SCHEMBL14025103 | 0.74 | KDM4E (0.45) | KDM4EALDH1A1PRMT5WDR77RORC | |
| SCHEMBL19063587 | 0.74 | KDM4E (0.45) | KDM4EALDH1A1PRMT5WDR77RORC | |
| SCHEMBL9888688 | 0.74 | KDM4E (0.56) | KDM4EALDH1A1PRMT5WDR77RORC | |
| SCHEMBL12219412 | 0.71 | KDM4E (0.51) | KDM4EALDH1A1PRMT5WDR77RORC | |
| SCHEMBL10022346 | 0.71 | KDM4E (0.54) | KDM4EALDH1A1RORCMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008143729-A2 | MACROLIDE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |