Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14023961 | 0.95 | RORC (0.44) | KDM4EALDH1A1RORCLMNAABHD6 | |
| SCHEMBL19063266 | 0.81 | ALDH1A1 (0.46) | KDM4EALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL14025104 | 0.80 | ACACB (0.43) | KDM4EALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL19062611 | 0.79 | ADRB1 (0.46) | KDM4EALDH1A1LMNADPP4 | |
| SCHEMBL14025098 | 0.79 | ADRB1 (0.46) | KDM4EALDH1A1LMNADPP4 | |
| SCHEMBL12551052 | 0.76 | KDM4E (0.54) | KDM4EALDH1A1RORCPRMT5WDR77 | |
| Hydrochloric Acid SCHEMBL20857074 | 0.74 | KDM4E (0.53) | KDM4EALDH1A1RORCPRMT5WDR77 | |
| SCHEMBL14025102 | 0.74 | KDM4E (0.47) | KDM4EALDH1A1RORCABHD6PRMT5 | |
| SCHEMBL14024028 | 0.73 | BCL2L1 (0.33) | LMNAKMT2ADPP4DPP7 | |
| SCHEMBL14023957 | 0.73 | DPP4 (0.36) | DPP4DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008143729-A2 | MACROLIDE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |