Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.61 |
| ▸ | HTR7 | P34969 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.56 |
| ▸ | LSS | P48449 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14025545 | 0.99 | ALDH1A1 (0.67) | ALDH1A1KDM4EPOLBLMNASMN1; SMN2 | |
| SCHEMBL4742905 | 0.88 | LMNA (0.62) | ALDH1A1KDM4EPOLBLMNASMN1; SMN2 | |
| SCHEMBL14025541 | 0.88 | LMNA (0.62) | ALDH1A1KDM4EPOLBLMNASMN1; SMN2 | |
| SCHEMBL4743359 | 0.88 | LMNA (0.62) | ALDH1A1KDM4EPOLBLMNASMN1; SMN2 | |
| SCHEMBL14025447 | 0.87 | LMNA (0.64) | ALDH1A1KDM4EPOLBLMNASMN1; SMN2 | |
| SCHEMBL14025724 | 0.86 | ALDH1A1 (0.63) | ALDH1A1KDM4EPOLBLMNASMN1; SMN2 | |
| SCHEMBL14025720 | 0.85 | ALDH1A1 (0.61) | ALDH1A1KDM4EPOLBLMNASMN1; SMN2 | |
| SCHEMBL12792999 | 0.80 | ALDH1A1 (0.97) | ALDH1A1KDM4EPOLBLMNASMN1; SMN2 | |
| SCHEMBL1874978 | 0.78 | TGM2 (0.55) | ALDH1A1KDM4EPOLBLMNASMN1; SMN2 | |
| SCHEMBL407414 | 0.78 | KEAP1 (1.00) | ALDH1A1KDM4EPOLBLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080261978-A1 | treating or preventing HIV infections, and in treating proliferative disorders such as inhibiting the metastasis of various cancers; 1-(4-((pyridin-2-ylmethylamino)methyl)benzyl)-3-phenylurea | METASTATIX, INC. | 2008-10-23 | — | — | US | disclosed |
| WO-2008109154-A1 | CHEMOKINE RECEPTOR MODULATORS | ALTIRIS THERAPEUTICS, INC. (US) | 2008-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261978-A1 | treating or preventing HIV infections, and in treating proliferative disorders such as inhibiting the metastasis of various cancers; 1-(4-((pyridin-2-ylmethylamino)methyl)benzyl)-3-phenylurea | MKI67, CCNI, CDKN1A | ALDH1A1 423/4885KDM4E 532/4885POLB 669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.