Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | NNMT | P40261 | 2/20 | 0.39 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13005277 | 0.72 | NNMT (0.44) | GRM5NNMTASIC3PIK3C3ALOX5AP | |
| SCHEMBL29951191 | 0.70 | NNMT (0.53) | GRM5NNMTASIC3PIK3C3ALOX5AP | |
| SCHEMBL14027114 | 0.70 | GRM5 (0.39) | GRM5NNMTASIC3 | |
| SCHEMBL4833036 | 0.68 | PIK3CA (0.40) | — | |
| SCHEMBL17173410 | 0.67 | NNMT (0.49) | NNMTPIK3C3 | |
| SCHEMBL13533931 | 0.67 | AHR (0.41) | GRM5NNMTASIC3ALOX5APFEN1 | |
| SCHEMBL17173454 | 0.66 | KMT2A (0.49) | GRM5NNMTPIK3C3 | |
| SCHEMBL620335 | 0.65 | CHRNB2 (0.48) | GRM5NNMTASIC3PIK3C3ALOX5AP | |
| SCHEMBL8927087 | 0.64 | CYP19A1 (0.41) | — | |
| SCHEMBL8385495 | 0.63 | ASIC3 (0.57) | GRM5NNMTASIC3PIK3C3ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |