Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRHR | P34981 | 1/20 | 0.54 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.49 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.48 |
| ▸ | REN | P00797 | 5/20 | 0.46 |
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4957150 | 0.87 | TRHR (0.70) | TRHRDPP4ACE2SLC15A2REN | |
| SCHEMBL8258003 | 0.86 | TRHR (0.54) | TRHRDPP4ACE2SLC15A2REN | |
| SCHEMBL14028674 | 0.84 | DPP4 (0.51) | TRHRDPP4ACE2RENLNPEP | |
| SCHEMBL14028661 | 0.81 | TRHR (0.78) | TRHRDPP4ACE2 | |
| SCHEMBL30294109 | 0.78 | TRHR (0.71) | TRHRDPP4ACE2REN | |
| SCHEMBL23312951 | 0.76 | SLC15A2 (0.61) | SLC15A2RENITGB2ICAM1ITGAL | |
| SCHEMBL30081493 | 0.75 | SLC15A2 (0.72) | SLC15A2EPHX2ITGB2ICAM1ITGAL | |
| SCHEMBL2197786 | 0.75 | SLC15A2 (0.72) | SLC15A2EPHX2ITGB2ICAM1ITGAL | |
| SCHEMBL30683534 | 0.74 | TRHR (0.73) | TRHRREN | |
| SCHEMBL4959538 | 0.72 | TRHR (0.64) | TRHRDPP4RENLNPEPCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080249028-A1 | Thyrotropin-Releasing Hormone Analogs and Method of Use | ROGER WILLIAMS HOSPITAL (US) | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249028-A1 | Thyrotropin-Releasing Hormone Analogs and Method of Use | TRHR, IAPP, TRHDE | TRHR 1/4885DPP4 81/4885ACE2 3810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.