Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.51 |
| ▸ | TRHR | P34981 | 1/20 | 0.50 |
| ▸ | REN | P00797 | 11/20 | 0.49 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
| ▸ | ANPEP | P15144 | 1/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4959538 | 0.89 | TRHR (0.64) | DPP4TRHRRENCTSDLNPEP | |
| SCHEMBL8256978 | 0.89 | TRHR (0.51) | DPP4TRHRRENCTSDLNPEP | |
| SCHEMBL14028673 | 0.84 | TRHR (0.54) | DPP4TRHRRENCTSDLNPEP | |
| SCHEMBL15381913 | 0.80 | RAMP3 (0.46) | RENCTSD | |
| SCHEMBL21828702 | 0.79 | CYP3A4 (0.57) | RENLNPEPACE2 | |
| SCHEMBL30595016 | 0.79 | CYP3A4 (0.57) | RENLNPEPACE2 | |
| SCHEMBL19345095 | 0.78 | TRHR (0.61) | TRHRRENCTSDLNPEP | |
| SCHEMBL14028661 | 0.77 | TRHR (0.78) | DPP4TRHRACE2 | |
| SCHEMBL29349749 | 0.76 | CYP3A4 (0.53) | RENLNPEPACE2 | |
| SCHEMBL4264574 | 0.75 | LNPEP (0.58) | TRHRRENCTSDLNPEPANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080249028-A1 | Thyrotropin-Releasing Hormone Analogs and Method of Use | ROGER WILLIAMS HOSPITAL (US) | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249028-A1 | Thyrotropin-Releasing Hormone Analogs and Method of Use | TRHR, IAPP, TRHDE | DPP4 81/4885TRHR 1/4885REN 426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.