Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRHR | P34981 | 1/20 | 0.64 |
| ▸ | REN | P00797 | 8/20 | 0.55 |
| ▸ | CTSD | P07339 | 1/20 | 0.52 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14028674 | 0.89 | DPP4 (0.51) | TRHRRENCTSDLNPEPDPP4 | |
| SCHEMBL19345095 | 0.89 | TRHR (0.61) | TRHRRENCTSDLNPEP | |
| SCHEMBL8256978 | 0.88 | TRHR (0.51) | TRHRRENCTSDLNPEPDPP4 | |
| SCHEMBL30294109 | 0.86 | TRHR (0.71) | TRHRRENDPP4 | |
| SCHEMBL4957150 | 0.83 | TRHR (0.70) | TRHRRENCTSDDPP4 | |
| Azetirelin SCHEMBL195158 | 0.80 | TRHR (0.85) | TRHR | |
| SCHEMBL8362438 | 0.80 | TRHR (0.68) | TRHRRENCTSD | |
| SCHEMBL30683534 | 0.80 | TRHR (0.73) | TRHRREN | |
| SCHEMBL21828702 | 0.79 | CYP3A4 (0.57) | RENLNPEP | |
| SCHEMBL30595016 | 0.79 | CYP3A4 (0.57) | RENLNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080249028-A1 | Thyrotropin-Releasing Hormone Analogs and Method of Use | ROGER WILLIAMS HOSPITAL (US) | 2008-10-09 | — | — | US | claimed |
| US-20080249028-A1 | Thyrotropin-Releasing Hormone Analogs and Method of Use | ROGER WILLIAMS HOSPITAL (US) | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249028-A1 | Thyrotropin-Releasing Hormone Analogs and Method of Use | TRHR, IAPP, TRHDE | TRHR 1/4885REN 426/4885CTSD 1269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.