Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.38 |
| ▸ | PLK3 | Q9H4B4 | 10/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4562904 | 0.89 | PLK1 (0.35) | PLK1PLK3IKBKECDK2CYP2C9 | |
| SCHEMBL4402730 | 0.89 | PLK1 (0.35) | PLK1PLK3IKBKECDK2CYP2C9 | |
| SCHEMBL3254457 | 0.83 | ALDH1A1 (0.38) | PLK1PLK3IKBKECDK2ALDH1A1 | |
| SCHEMBL4632609 | 0.82 | PLK1 (0.35) | PLK1PLK3IKBKECDK2CYP2C9 | |
| SCHEMBL4632611 | 0.82 | PLK1 (0.35) | PLK1PLK3IKBKECDK2CYP2C9 | |
| SCHEMBL3146777 | 0.81 | PKM (0.41) | PLK1PLK3IKBKECDK2ALDH1A1 | |
| SCHEMBL5582470 | 0.79 | AKR1B10 (0.39) | PLK1PLK3IKBKECDK2CYP2C9 | |
| SCHEMBL2982204 | 0.79 | AKR1B10 (0.39) | PLK1PLK3IKBKECDK2CYP2C9 | |
| SCHEMBL13592863 | 0.79 | BACE1 (0.38) | PLK1PLK3IKBKECDK2ALDH1A1 | |
| SCHEMBL3265422 | 0.79 | MEN1 (0.40) | PLK1PLK3IKBKECDK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080249301-A1 | Regioselective Process for Preparing Benzimidazole Thiophenes | SMITHKLINE BEECHAM CORPORATION | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249301-A1 | Regioselective Process for Preparing Benzimidazole Thiophenes | CYP3A4, CYP2C19, CYP2B6 | PLK1 1718/4885PLK3 2097/4885IKBKE 1819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.