Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | F12 | P00748 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27364207 | 0.77 | LMNA (0.48) | ALDH1A1BLMRECQLCYP2C19CYP3A4 | |
| SCHEMBL28066941 | 0.75 | CES2 (0.48) | ALDH1A1RECQLMAPTCES1CES2 | |
| SCHEMBL1076339 | 0.74 | AKT1 (0.52) | TDP1ALDH1A1MAPK1BLMTSHR | |
| SCHEMBL28163551 | 0.73 | PARP1 (0.62) | ALDH1A1PARP1L3MBTL1PKMCES1 | |
| SCHEMBL8519178 | 0.72 | ALDH1A1 (0.59) | TDP1ALDH1A1MAPK1BLMTSHR | |
| SCHEMBL9615018 | 0.72 | ALDH1A1 (0.59) | TDP1ALDH1A1MAPK1BLMTSHR | |
| SCHEMBL9615016 | 0.72 | ALDH1A1 (0.59) | TDP1ALDH1A1MAPK1BLMTSHR | |
| SCHEMBL28054631 | 0.72 | ALDH1A1 (0.59) | TDP1ALDH1A1MAPK1BLMTSHR | |
| Benzamide SCHEMBL8772889 | 0.72 | PARP1 (0.80) | TDP1ALDH1A1MAPK1BLMTSHR | |
| Benzamide SCHEMBL3541486 | 0.72 | PARP1 (0.80) | TDP1ALDH1A1MAPK1BLMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291359-A1 | PHENYL OR PYRIDINYL SUBSTITUTED INDAZOLES DERIVATIVES | AstraZeneca AB (SE) | 2011-03-09 | — | — | EP | claimed |
| US-20100080786-A1 | Phenyl or Pyridinyl Substituted Indazoles Derivatives | ASTRAZENECA AB (SE) | 2010-04-01 | — | — | US | claimed |
| WO-2009142569-A1 | PHENYL OR PYRIDINYL SUBSTITUTED INDAZOLES DERIVATIVES | ASTRAZENECA AB (SE) | 2009-11-26 | — | — | WO | claimed |
| CN-116234810-A | Cell apoptosis inhibitor and preparation method and application thereof | 中国科学院上海有机化学研究所 | 2023-06-06 | — | — | CN | disclosed |
| EP-2291359-A1 | PHENYL OR PYRIDINYL SUBSTITUTED INDAZOLES DERIVATIVES | AstraZeneca AB (SE) | 2011-03-09 | — | — | EP | disclosed |
| CN-101967117-A | Substituted pyrrole derivatives and their use as HMG-CO inhibitors | RANBAXY LAB LTD | 2011-02-09 | — | — | CN | disclosed |
| US-20100080786-A1 | Phenyl or Pyridinyl Substituted Indazoles Derivatives | ASTRAZENECA AB (SE) | 2010-04-01 | — | — | US | disclosed |
| WO-2009142569-A1 | PHENYL OR PYRIDINYL SUBSTITUTED INDAZOLES DERIVATIVES | ASTRAZENECA AB (SE) | 2009-11-26 | — | — | WO | disclosed |
| CN-1812983-A | Substituted pyrrole derivatives and their use as hmg-co inhibitors | RANBAXY LAB LTD (IN) | 2006-08-02 | — | — | CN | disclosed |
| CN-1042331-C | Indole derivatives | GLAXO SPA (IT) | 1999-03-03 | — | — | CN | disclosed |
| CN-1041919-C | N-(3-piperidinylcarbonyl)-beta-alanine derivatives as PAF antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-02-03 | — | — | CN | disclosed |
| CN-1116847-A | N- (3-piperidinylcarbonyl) -beta-aminopropionic acid derivatives as PAF antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-02-14 | — | — | CN | disclosed |
| CN-1085212-A | Indole derivatives | GLAXO SPA (IT) | 1994-04-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100080786-A1 | Phenyl or Pyridinyl Substituted Indazoles Derivatives | CYP3A5, CYP3A43, ABCB1 | TDP1 3856/4885ALDH1A1 612/4885MAPK1 2951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.