Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | CASP1 | P29466 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 3/20 | 0.54 |
| ▸ | LDHA | P00338 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 9/20 | 0.51 |
| ▸ | MMP12 | P39900 | 9/20 | 0.51 |
| ▸ | MMP8 | P22894 | 8/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593428 | 0.83 | PKM (0.55) | GAAALDH1A1PKMMMP2MMP12 | |
| SCHEMBL4593546 | 0.82 | LDHA (0.59) | GAAGFERHKDC1L3MBTL1LDHA | |
| SCHEMBL10693393 | 0.82 | LDHA (0.63) | GAAGFERHKDC1L3MBTL1LDHA | |
| SCHEMBL17962282 | 0.81 | COMT (0.74) | GAAMAPTSMN1; SMN2MITFMEN1 | |
| SCHEMBL10592283 | 0.81 | GAA (0.61) | GAAALDH1A1SMN1; SMN2PKMMMP2 | |
| SCHEMBL7085229 | 0.78 | LDHA (0.73) | HKDC1L3MBTL1LDHAMEN1KMT2A | |
| SCHEMBL7198914 | 0.77 | LDHA (0.53) | GAAGFERHKDC1L3MBTL1LDHA | |
| SCHEMBL7545258 | 0.77 | LDHA (0.53) | GAAHSD17B10GFERHKDC1LDHA | |
| SCHEMBL8509876 | 0.76 | GAA (0.50) | GAAALDH1A1SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL21511039 | 0.75 | GAA (1.00) | GAAALDH1A1TP53MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-10-16 | — | — | US | disclosed |
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | APP, BACE1, SNCA | GAA 38/4885ALDH1A1 1775/4885TP53 740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.