Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | ALPL | P05186 | 1/20 | 0.53 |
| ▸ | ALPI | P09923 | 1/20 | 0.53 |
| ▸ | ALPG | P10696 | 1/20 | 0.53 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.50 |
| ▸ | COMT | P21964 | 2/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10693393 | 0.89 | LDHA (0.63) | LDHAPOLBGAAGFERALPL | |
| SCHEMBL7085229 | 0.85 | LDHA (0.73) | LDHAALPLALPIALPGDNMT1 | |
| SCHEMBL7545258 | 0.83 | LDHA (0.53) | LDHAPOLBGAAGFERHKDC1 | |
| SCHEMBL7198914 | 0.83 | LDHA (0.53) | LDHAPOLBGAAGFERALPL | |
| Formaldehyde SCHEMBL15348636 | 0.83 | HKDC1 (0.50) | LDHAPOLBGAAGFERALPL | |
| SCHEMBL8510632 | 0.83 | RAPGEF4 (0.47) | POLBGAAGFERALPLALPI | |
| SCHEMBL8509341 | 0.83 | POLB (0.45) | POLBGAAGFERALPLALPI | |
| SCHEMBL14030697 | 0.82 | GAA (0.60) | LDHAPOLBGAAGFERL3MBTL1 | |
| SCHEMBL7184588 | 0.80 | GAA (0.41) | LDHAPOLBGAAGFERALPL | |
| SCHEMBL8509876 | 0.79 | GAA (0.50) | GAAL3MBTL1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-10-16 | — | — | US | claimed |
| EP-1937243-A2 | NAPHTHYL DERIVATIVES AS INHIBITORS OF BETA-AMYLOID AGGREGATION | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2008-07-02 | — | — | EP | claimed |
| WO-2007045593-A2 | NAPHTHYL DERIVATIVES AS INHIBITORS OF BETA-AMYLOID AGGREGATION | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-04-26 | — | — | WO | claimed |
| US-4996279-A | Crosslinked epoxies from diepoxides, diphenols, primary and secondary amines with stiff and flexible units; melt processability | SHELL OIL COMPANY (US) | 1991-02-26 | — | — | US | claimed |
| CN-101291665-A | Naphthyl derivatives as inhibitors of beta-amyloid aggregation | SIGMA TAU IND FARMACEUTI (IT) | 2008-10-22 | — | — | CN | disclosed |
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-10-16 | — | — | US | disclosed |
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-10-16 | — | — | US | disclosed |
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-10-16 | — | — | US | disclosed |
| EP-1937243-A2 | NAPHTHYL DERIVATIVES AS INHIBITORS OF BETA-AMYLOID AGGREGATION | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007045593-A2 | NAPHTHYL DERIVATIVES AS INHIBITORS OF BETA-AMYLOID AGGREGATION | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-04-26 | — | — | WO | disclosed |
| WO-2007045593-A2 | NAPHTHYL DERIVATIVES AS INHIBITORS OF BETA-AMYLOID AGGREGATION | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-04-26 | — | — | WO | disclosed |
| EP-1304924-A2 | COMPOSITIONS FOR REPELLING CRAWLING INSECTS | Bayer Aktiengesellschaft (DE) | 2003-05-02 | — | — | EP | disclosed |
| EP-0608579-A1 | A heat and light sensitive imaging element | AGFA-GEVAERT N.V. (BE) | 1994-08-03 | — | — | EP | disclosed |
| EP-0599368-A1 | Thermal imaging method | AGFA-GEVAERT N.V. (BE) | 1994-06-01 | — | — | EP | disclosed |
| EP-0582753-A1 | Heat- and photosensitive imaging element | AGFA-GEVAERT N.V. (BE) | 1994-02-16 | — | — | EP | disclosed |
| EP-0252691-B1 | HEAT-SENSITIVE RECORD MATERIAL | KANZAKI PAPER MANUFACTURING COMPANY LIMITED (JP) | 1991-09-18 | — | — | EP | disclosed |
| US-4996279-A | Crosslinked epoxies from diepoxides, diphenols, primary and secondary amines with stiff and flexible units; melt processability | SHELL OIL COMPANY (US) | 1991-02-26 | — | — | US | disclosed |
| US-4960912-A | EPOXY RESINS, POLYEPOXDIES | SHELL OIL COMPANY (US) | 1990-10-02 | — | — | US | disclosed |
| US-4771033-A | CHROMOGEN, PHENOL COMPOUND, ACIDIC ACCEPTOR ON A BASE SHEET | KANZAKI PAPER MANUFACTURING CO., LTD. (JP) | 1988-09-13 | — | — | US | disclosed |
| EP-0252691-A2 | Heat-sensitive record material | KANZAKI PAPER MANUFACTURING COMPANY LIMITED (JP) | 1988-01-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | APP, BACE1, SNCA | LDHA 2001/4885POLB 1245/4885GAA 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.