Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 8/20 | 0.49 |
| ▸ | MMP12 | P39900 | 8/20 | 0.49 |
| ▸ | MMP8 | P22894 | 7/20 | 0.49 |
| ▸ | MMP13 | P45452 | 7/20 | 0.49 |
| ▸ | MMP14 | P50281 | 7/20 | 0.49 |
| ▸ | MMP16 | P51512 | 7/20 | 0.49 |
| ▸ | MMP9 | P14780 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.48 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 4/20 | 0.46 |
| ▸ | MMP1 | P03956 | 3/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | FABP4 | P15090 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8509876 | 0.86 | GAA (0.50) | PKMHTR6ALDH1A1NPC1GAA | |
| SCHEMBL14030697 | 0.83 | GAA (0.60) | PKMMMP2MMP12MMP8MMP13 | |
| SCHEMBL931939 | 0.80 | HTR6 (0.77) | PKMHTR6MMP2MMP12MMP8 | |
| SCHEMBL1415941 | 0.77 | ALDH1A1 (0.54) | ALDH1A1NPC1KEAP1NFE2L2GAA | |
| SCHEMBL30493510 | 0.77 | ALDH1A1 (0.54) | ALDH1A1NPC1KEAP1NFE2L2GAA | |
| Potassium Ion SCHEMBL13719096 | 0.77 | ALDH1A1 (0.54) | ALDH1A1NPC1KEAP1NFE2L2GAA | |
| SCHEMBL2568338 | 0.77 | ALDH1A1 (0.54) | ALDH1A1NPC1KEAP1NFE2L2GAA | |
| SCHEMBL31425582 | 0.77 | ALDH1A1 (0.54) | ALDH1A1NPC1KEAP1NFE2L2GAA | |
| SCHEMBL30855487 | 0.76 | ALDH1A1 (0.56) | ALDH1A1NPC1GAAMAPK1FABP4 | |
| SCHEMBL15461561 | 0.76 | ALDH1A1 (0.56) | ALDH1A1NPC1GAAMAPK1FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-10-16 | — | — | US | claimed |
| EP-1937243-A2 | NAPHTHYL DERIVATIVES AS INHIBITORS OF BETA-AMYLOID AGGREGATION | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2008-07-02 | — | — | EP | claimed |
| WO-2007045593-A2 | NAPHTHYL DERIVATIVES AS INHIBITORS OF BETA-AMYLOID AGGREGATION | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-04-26 | — | — | WO | claimed |
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-10-16 | — | — | US | disclosed |
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-10-16 | — | — | US | disclosed |
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-10-16 | — | — | US | disclosed |
| EP-1937243-A2 | NAPHTHYL DERIVATIVES AS INHIBITORS OF BETA-AMYLOID AGGREGATION | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007045593-A2 | NAPHTHYL DERIVATIVES AS INHIBITORS OF BETA-AMYLOID AGGREGATION | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-04-26 | — | — | WO | disclosed |
| WO-2007045593-A2 | NAPHTHYL DERIVATIVES AS INHIBITORS OF BETA-AMYLOID AGGREGATION | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-04-26 | — | — | WO | disclosed |
| US-4996279-A | Crosslinked epoxies from diepoxides, diphenols, primary and secondary amines with stiff and flexible units; melt processability | SHELL OIL COMPANY (US) | 1991-02-26 | — | — | US | disclosed |
| US-4960912-A | EPOXY RESINS, POLYEPOXDIES | SHELL OIL COMPANY (US) | 1990-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | APP, BACE1, SNCA | PKM 3038/4885HTR6 2660/4885MMP2 1627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.