Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | F12 | P00748 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5070051 | 0.86 | ADORA1 (0.49) | PARP1TNKS2PARP2ADORA1ESR2 | |
| SCHEMBL13070458 | 0.81 | ADORA1 (0.53) | PARP1TNKS2PARP2ADORA1ESR2 | |
| SCHEMBL23794808 | 0.81 | PARP1 (0.46) | PARP1TNKS2PARP2ADORA1ESR2 | |
| SCHEMBL5069421 | 0.81 | F12 (0.44) | PARP1TNKS2PARP2ADORA1NR1H2 | |
| SCHEMBL22074889 | 0.80 | PARP1 (0.45) | PARP1TNKS2PARP2ADORA1ESR2 | |
| SCHEMBL22492346 | 0.80 | ADORA1 (0.50) | PARP1TNKS2PARP2ADORA1ESR2 | |
| SCHEMBL5070030 | 0.80 | F12 (0.41) | PARP1TNKS2PARP2ADORA1ESR2 | |
| SCHEMBL29386147 | 0.79 | RBP4 (0.42) | PARP1TNKS2PARP2ADORA1ESR2 | |
| SCHEMBL28700403 | 0.78 | L3MBTL1 (0.41) | PARP1TNKS2PARP2ADORA1ESR2 | |
| SCHEMBL23794846 | 0.78 | PARP1 (0.44) | PARP1TNKS2PARP2ADORA1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |