Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14033926 | 0.85 | P2RX7 (0.44) | P2RX7TRPV4BRD4 | |
| SCHEMBL14803652 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2P2RX7ADORA2AADORA1CA12 | |
| SCHEMBL14033326 | 0.79 | P2RX7 (0.48) | P2RX7TRPV4HDAC4ATM | |
| SCHEMBL28009191 | 0.79 | P2RX7 (0.45) | P2RX7TRPV4HDAC4ATM | |
| SCHEMBL16462564 | 0.77 | P2RX7 (0.52) | P2RX7TRPV4 | |
| SCHEMBL28869188 | 0.77 | TRPV4 (0.48) | P2RX7TRPV4BRD4 | |
| SCHEMBL27823408 | 0.77 | TRPV4 (0.48) | P2RX7TRPV4BRD4 | |
| SCHEMBL30003924 | 0.77 | TRPV4 (0.48) | P2RX7TRPV4BRD4 | |
| SCHEMBL485441 | 0.77 | TRPV4 (0.48) | P2RX7TRPV4BRD4 | |
| SCHEMBL16463713 | 0.76 | ALDH1A1 (0.46) | SMN1; SMN2P2RX7TRPV4ATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |