SCHEMBL1403594

SCHEMBL1403594

[CH2]Oc1ccc(NC(C)=O)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.68
MEN1 O00255 4/20 0.68
TDP1 Q9NUW8 2/20 0.61
LMNA P02545 1/20 0.61
CYP1A2 P05177 1/20 0.61
SMN1; SMN2 Q16637 5/20 0.59
HTT P42858 1/20 0.59
L3MBTL1 Q9Y468 1/20 0.59
CA1 P00915 2/20 0.58
CA2 P00918 2/20 0.58
CA9 Q16790 2/20 0.58
NPSR1 Q6W5P4 1/20 0.58
ALDH1A1 P00352 5/20 0.57
MAPT P10636 4/20 0.57
CA12 O43570 1/20 0.57
BRD4 O60885 1/20 0.57
NR1I2 O75469 1/20 0.57
MB P02144 1/20 0.57
CYP1A1 P04798 1/20 0.57
CA3 P07451 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6516221 0.83 KMT2A (0.73) KMT2AMEN1TDP1LMNACYP1A2
SCHEMBL20769833 0.82 KMT2A (0.79) KMT2AMEN1TDP1LMNACYP1A2
SCHEMBL861674 0.82 SMN1; SMN2 (0.84) KMT2AMEN1TDP1SMN1; SMN2HTT
SCHEMBL171415 0.81 SMN1; SMN2 (0.73) KMT2AMEN1TDP1LMNACYP1A2
SCHEMBL14808444 0.81 KMT2A (1.00) KMT2AMEN1TDP1LMNACYP1A2
SCHEMBL15887274 0.79 KMT2A (0.68) KMT2AMEN1TDP1LMNACYP1A2
Diacetamate SCHEMBL863106 0.79 KMT2A (0.81) KMT2AMEN1TDP1LMNACYP1A2
SCHEMBL22765830 0.79 KMT2A (0.68) KMT2AMEN1TDP1LMNACYP1A2
SCHEMBL5612835 0.79 KMT2A (0.61) KMT2AMEN1TDP1LMNACYP1A2
SCHEMBL1064813 0.79 KMT2A (0.71) KMT2AMEN1TDP1LMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240207411-A1 LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS SEAPORT THERAPEUTICS, INC. 2024-06-27 US disclosed
US-11883497-B2 Lymphatic system-directing lipid prodrugs PURETECH LYT, INC. (US) 2024-01-30 US disclosed
EP-4306524-A2 LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS PureTech LYT, Inc. (US) 2024-01-17 EP disclosed
US-20220001015-A1 LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS SEAPORT THERAPEUTICS, INC. 2022-01-06 US disclosed
US-11021498-B2 Water-soluble acetaminophen analogs ACORDA THERAPEUTICS, INC. (US) 2021-06-01 US disclosed
EP-3675838-A1 LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS Puretecch LYT, Inc. (US) 2020-07-08 EP disclosed
US-10442826-B2 Water-soluble acetaminophen analogs ACORDA THERAPEUTICS, INC. (US) 2019-10-15 US disclosed
US-20190092795-A1 WATER-SOLUBLE ACETAMINOPHEN ANALOGS NEUROGESX, INC. 2019-03-28 US disclosed
WO-2019046491-A1 LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS ARIYA THERAPEUTICS, INC. (US) 2019-03-07 WO disclosed
US-9981998-B2 Water-soluble acetaminophen analogs ACORDA THERAPEUTICS, INC. (US) 2018-05-29 US disclosed
EP-2291348-A1 WATER-SOLUBLE ACETAMINOPHEN ANALOGS Neurogesx, Inc. (US) 2011-03-09 EP disclosed
US-20100210637-A1 HETEROARYLOXY NITROGENOUS SATURATED HETEROCYCLIC DERIVATIVE MSD K.K. (JP) 2010-08-19 US disclosed
WO-2009143295-A1 WATER-SOLUBLE ACETAMINOPHEN ANALOGS NEUROGESX, INC. (US) 2009-11-26 WO disclosed
US-7595316-B2 Heteroaryloxy nitrogenous saturated heterocyclic derivative BANYU PHARMACEUTICAL CO., LTD. (JP) 2009-09-29 US disclosed
EP-1678185-B1 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS OTSUKA PHARMA CO LTD (JP) 2008-10-08 EP disclosed
US-20080119478-A1 2,3-Dihydro-6-Nitroimidazo (2,1-b) Oxazole Compounds for the Treatment of Tuberculosis OTSUKA PHAMACEUTICAL CO., LTD. (JP) 2008-05-22 US disclosed
US-20060178375-A1 Heteroaryloxy nitrogenous saturated heterocyclic derivative MSD K.K. (JP) 2006-08-10 US disclosed
EP-1642898-A1 HETEROARYLOXY NITROGENOUS SATURATED HETEROCYCLIC DERIVATIVE BANYU PHARMACEUTICAL CO., LTD. (JP) 2006-04-05 EP disclosed
EP-0276124-B1 PROSTAGLANDIN DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE Sankyo Company Limited (JP) 1992-05-20 EP disclosed
US-4981872-A ANTIULCER SANKYO COMPANY LIMITED (JP) 1991-01-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220001015-A1 LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS LIPA, MALT1, SGMS1 KMT2A 2872/4885MEN1 1498/4885TDP1 1025/4885
US-10442826-B2 Water-soluble acetaminophen analogs PTGS1, HPGD, PYGL KMT2A 4336/4885MEN1 4365/4885TDP1 2279/4885
US-11021498-B2 Water-soluble acetaminophen analogs PTGS1, HPGD, PYGL KMT2A 4336/4885MEN1 4365/4885TDP1 2279/4885
US-20080119478-A1 2,3-Dihydro-6-Nitroimidazo (2,1-b) Oxazole Compounds for the Treatment of Tuberculosis NR2C2, NR0B2, NR4A2 KMT2A 3324/4885MEN1 4525/4885TDP1 4548/4885
US-20060178375-A1 Heteroaryloxy nitrogenous saturated heterocyclic derivative HRH3, HRH4, HCRTR2 KMT2A 423/4885MEN1 1981/4885TDP1 4743/4885
US-20100210637-A1 HETEROARYLOXY NITROGENOUS SATURATED HETEROCYCLIC DERIVATIVE HRH3, HRH4, HRH2 KMT2A 552/4885MEN1 1602/4885TDP1 4726/4885
US-20190092795-A1 WATER-SOLUBLE ACETAMINOPHEN ANALOGS PTGS1, HPGD, PYGL KMT2A 4336/4885MEN1 4365/4885TDP1 2279/4885
US-11883497-B2 Lymphatic system-directing lipid prodrugs LIPA, MALT1, SGMS1 KMT2A 2872/4885MEN1 1498/4885TDP1 1025/4885
US-20240207411-A1 LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS LIPA, MALT1, SGMS1 KMT2A 2872/4885MEN1 1498/4885TDP1 1025/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.