Sugi Predict

Sugi Predict / Compounds / SCHEMBL1403615

SCHEMBL1403615

SCHEMBL1403615

COC(=O)c1ccc([N+](=O)[O-])cn1

nearest known ligand 0.59

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ CYP2C19 P33261 2/20 0.59
▸ MAPK1 P28482 2/20 0.57
▸ CYP1A2 P05177 1/20 0.54
▸ GAA P10253 1/20 0.54
▸ MAPT P10636 5/20 0.53
▸ POLB P06746 2/20 0.49
▸ NPC1 O15118 2/20 0.48
▸ RAB9A P51151 2/20 0.48
▸ MEN1 O00255 3/20 0.48
▸ KMT2A Q03164 3/20 0.48
▸ KDM4E B2RXH2 2/20 0.47
▸ HTT P42858 1/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.46
▸ PABPC1 P11940 2/20 0.46
▸ P4HTM Q9NXG6 1/20 0.46
▸ PKM P14618 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30232741 1.00 CYP2C19 (0.59) CYP2C19MAPK1CYP1A2GAAMAPT
SCHEMBL6014107 0.85 MEN1 (0.51) CYP2C19MAPK1MAPTPOLBNPC1
SCHEMBL11633754 0.84 MAPT (0.51) CYP2C19MAPK1MAPTPOLBNPC1
SCHEMBL17673994 0.84 CYP2C19 (0.49) CYP2C19CYP1A2GAAMAPTNPC1
SCHEMBL28679657 0.83 CYP2C19 (0.48) CYP2C19CYP1A2GAAMAPTNPC1
SCHEMBL18160680 0.83 CYP2C19 (0.48) CYP2C19CYP1A2GAAMAPTNPC1
SCHEMBL3313819 0.83 MAPT (0.60) CYP2C19CYP1A2GAAMAPTPOLB
SCHEMBL15956178 0.83 CYP2C19 (0.55) CYP2C19CYP1A2GAAMAPTNPC1
SCHEMBL6163873 0.81 CYP1A2 (0.58) CYP2C19MAPK1CYP1A2GAAMAPT
SCHEMBL28636837 0.80 PKM (0.53) CYP2C19MAPK1CYP1A2GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 177 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10364300-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2019-07-30 — — US claimed
US-20170247478-A1 Method For Producing Polydienes And Polydiene Copolymers With Reduced Cold Flow BRIDGESTONE CORPORATION (JP) 2017-08-31 — — US claimed
EP-3204429-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW Bridgestone Corporation (JP) 2017-08-16 — — EP claimed
WO-2016057388-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2016-04-14 — — WO claimed
EP-4415816-B1 PYRROLO[2,1-F][1,2,4]TRIAZINES DERIVATIVES AS INHIBITORS OF DYRK1A BIOSPLICE THERAPEUTICS INC (US) 2026-03-18 — — EP disclosed
US-12472181-B2 Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders GALAPAGOS NV (BE) 2025-11-18 — — US disclosed
CN-120076693-A Photovoltaic device, photovoltaic module, power generation device and power utilization device 宁德时代新能源科技股份有限公司 2025-05-30 — — CN disclosed
US-20250171466-A1 PYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF TENARX, INC. 2025-05-29 — — US disclosed
US-20250129104-A1 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AND USES THEREOF TENARX, INC. 2025-04-24 — — US disclosed
US-12134625-B2 Pyrrolo[2,1-f][1,2,4]triazines and preparation and uses thereof BIOSPLICE THERAPEUTICS, INC. (US) 2024-11-05 — — US disclosed
EP-4415816-A1 PYRROLO[2,1-F][1,2,4]TRIAZINES DERIVATIVES AS INHIBITORS OF DYRK1A BioSplice Therapeutics, Inc. (US) 2024-08-21 — — EP disclosed
EP-4415818-A1 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS BioSplice Therapeutics, Inc. (US) 2024-08-21 — — EP disclosed
EP-0588357-A1 Isoxazoles derivatives and their use as herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1994-03-23 — — EP disclosed
US-4923504-A 2-(2-Imidazolin-2-yl)pyridines and quinolines, and use of said compounds as herbicidal agents AMERICAN CYANAMID COMPANY (US) 1990-05-08 — — US disclosed
US-4798619-A 2-(2-imidazolin-2-yl)-pyridines and quinolines and use of said compounds as herbicidal agents AMERICAN CYANAMID CO. (US) 1989-01-17 — — US disclosed
US-4638068-A 2-(2-imidazolin-2-yl)-pyridines and quinolines, process and intermediates for the preparation thereof, and use of said compounds as herbicidal agents AMERICAN CYANAMID COMPANY (US) 1987-01-20 — — US disclosed
US-4260620-A HYPOTENSIVE AGENTS CIBA-GEIGY CORPORATION (US) 1981-04-07 — — US disclosed
US-4202901-A HYPOTENSIVE AGENTS CIBA-GEIGY CORPORATION (US) 1980-05-13 — — US disclosed
US-4197302-A HYPOTENSIVE AGENTS, 5-ETHERIFIED, ALSO ESTERS, AMIDES, HYDRAZIDES CIBA-GEIGY CORPORATION (US) 1980-04-08 — — US disclosed
US-4036965-A HYPOTENSIVE AGENTS CIBA-GEIGY CORPORATION (US) 1977-07-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250171466-A1 PYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF DYRK1A, DYRK2, DYRK1B CYP2C19 4663/4885MAPK1 695/4885CYP1A2 3748/4885
US-20250129104-A1 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AND USES THEREOF DYRK1A, DYRK1B, DYRK2 CYP2C19 3374/4885MAPK1 1046/4885CYP1A2 3655/4885
US-12472181-B2 Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders IL15, IL2, IL33 CYP2C19 232/4885MAPK1 3635/4885CYP1A2 275/4885
US-12134625-B2 Pyrrolo[2,1-f][1,2,4]triazines and preparation and uses thereof DYRK1A, DYRK2, DYRK1B CYP2C19 4663/4885MAPK1 695/4885CYP1A2 3748/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.