Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | QPCT | Q16769 | 3/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14036546 | 0.90 | NPC1 (0.52) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL14036562 | 0.86 | KMT2A (0.39) | NPC1RAB9AKMT2AMEN1MAPK1 | |
| SCHEMBL14036567 | 0.85 | TACR1 (0.35) | KMT2AMEN1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL14036789 | 0.83 | PTPN1 (0.41) | KMT2AMEN1MAPK1LMNAMAPT | |
| SCHEMBL14036571 | 0.83 | TP53 (0.41) | MAPTPOLB | |
| SCHEMBL23585337 | 0.76 | ACHE (0.41) | KMT2AMAPK1LMNAPOLB | |
| SCHEMBL14036558 | 0.76 | KMT2A (0.37) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL14036556 | 0.71 | UBE2M (0.40) | MAPTPOLB | |
| SCHEMBL14036544 | 0.70 | TP53 (0.46) | LMNAMAPT | |
| SCHEMBL14036542 | 0.66 | UBE2M (0.36) | RAB9ALMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008137102-A2 | METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR | TORREYPINES THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |