Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | DDX3X | O00571 | 1/20 | 0.37 |
| ▸ | UBE2M | P61081 | 7/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14036632 | 0.89 | TP53 (0.40) | TP53MAPTPOLBSMN1; SMN2DDX3X | |
| SCHEMBL14036574 | 0.87 | TP53 (0.44) | TP53MAPTPOLBSMN1; SMN2DDX3X | |
| SCHEMBL14036573 | 0.85 | TP53 (0.41) | TP53MAPTPOLBSMN1; SMN2DDX3X | |
| SCHEMBL14036560 | 0.85 | TP53 (0.41) | TP53MAPTPOLBSMN1; SMN2DDX3X | |
| SCHEMBL14036635 | 0.84 | TP53 (0.39) | TP53MAPTPOLBSMN1; SMN2DDX3X | |
| SCHEMBL14036575 | 0.73 | DDX3X (0.40) | MAPTPOLBDDX3XUSP2ALDH1A1 | |
| SCHEMBL14036683 | 0.71 | PSEN1 (0.50) | TP53MAPTPOLBUSP2ALDH1A1 | |
| SCHEMBL23200254 | 0.71 | UBE2M (0.42) | TP53MAPTPOLBDDX3XUBE2M | |
| SCHEMBL14036695 | 0.67 | PSEN1 (0.54) | UBE2MDCUN1D1 | |
| SCHEMBL14036631 | 0.64 | MAPK1 (0.42) | POLBSMN1; SMN2DDX3XKDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008137102-A2 | METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR | TORREYPINES THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |