Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | RORC | P51449 | 5/20 | 0.42 |
| ▸ | RORA | P35398 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | RORB | Q92753 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17029652 | 0.84 | NPY5R (0.46) | RORCHPGDSMN1; SMN2LMNAHTT | |
| SCHEMBL4770454 | 0.76 | CNR2 (0.49) | CNR2RORCSMN1; SMN2LMNAHTT | |
| SCHEMBL2996700 | 0.76 | CNR2 (0.49) | CNR2RORCSMN1; SMN2LMNAHTT | |
| SCHEMBL3192672 | 0.75 | CNR2 (0.65) | CNR2RORCRORANR1H2NR1H3 | |
| SCHEMBL17029673 | 0.74 | HPGD (0.44) | HPGDSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL17029656 | 0.70 | HTT (0.42) | HPGDSMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL2997991 | 0.70 | LOXL2 (0.47) | CNR2HTTMEN1KMT2A | |
| SCHEMBL595710 | 0.69 | HPGD (0.52) | HPGDSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5295877 | 0.69 | CNR2 (0.54) | CNR2RORCRORANR1H2NR1H3 | |
| SCHEMBL2788574 | 0.68 | SERPINE1 (0.58) | CNR2HPGDLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137164-B1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2015-08-26 | — | — | EP | disclosed |
| WO-2008129069-A1 | INHIBITORS OF PROTEIN KINASES | INGENIUM PHARMACEUTICALS GMBH (DE) | 2008-10-30 | — | — | WO | disclosed |