Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 4/20 | 0.46 |
| ▸ | FPR1 | P21462 | 2/20 | 0.46 |
| ▸ | GCK | P35557 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14040637 | 1.00 | FPR2 (0.46) | FPR2FPR1GCKCA2CA9 | |
| SCHEMBL4698135 | 0.71 | USP5 (0.44) | MMP2MMP13MMP3KMT2A | |
| Bicarbonate SCHEMBL2767431 | 0.71 | MMP14 (0.46) | FPR2FPR1GCKCA2CA9 | |
| SCHEMBL4698660 | 0.71 | CA2 (0.56) | GCKCA2CA9CA12GAA | |
| SCHEMBL6242244 | 0.69 | CA2 (0.54) | GCKCA2CA9CA12GAA | |
| SCHEMBL4700945 | 0.69 | CA2 (0.54) | GCKCA2CA9CA12GAA | |
| SCHEMBL6058671 | 0.68 | ADAMTS5 (0.50) | GCKCA2CA9CA12GAA | |
| SCHEMBL2764220 | 0.68 | ADAMTS5 (0.50) | GCKCA2CA9CA12GAA | |
| SCHEMBL2764219 | 0.68 | ADAMTS5 (0.50) | GCKCA2CA9CA12GAA | |
| SCHEMBL2156809 | 0.68 | KDM4E (0.55) | FPR2FPR1GCKCA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444202-B1 | NOVEL METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-10-15 | — | — | EP | disclosed |