Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972671 | 0.96 | TACR1 (0.51) | TACR1HPGDKMT2AALDH1A1ALOX15 | |
| SCHEMBL7975015 | 0.86 | HPGD (0.56) | TACR1HPGDKMT2AALDH1A1HTT | |
| SCHEMBL7975013 | 0.86 | HPGD (0.56) | TACR1HPGDKMT2AALDH1A1HTT | |
| SCHEMBL7975009 | 0.86 | HPGD (0.56) | TACR1HPGDKMT2AALDH1A1HTT | |
| SCHEMBL14040973 | 0.84 | BLM (0.43) | LMNANPSR1 | |
| SCHEMBL14040951 | 0.81 | THRB (0.39) | TACR1HPGDKMT2AALDH1A1LMNA | |
| SCHEMBL7774834 | 0.81 | HPGD (0.41) | TACR1HPGDKMT2AALDH1A1LMNA | |
| SCHEMBL17887874 | 0.78 | LMNA (0.48) | TACR1HPGDKMT2AALDH1A1LMNA | |
| SCHEMBL7974337 | 0.78 | L3MBTL1 (0.58) | HPGDKMT2AALOX15LMNAMEN1 | |
| SCHEMBL4385039 | 0.77 | TRPV1 (0.36) | HPGDKMT2ASMN1; SMN2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318983-B1 | SUBSTITUTED IMIDAZOLES AS HISTAMINE H1 AND H3 AGONISTS OR ANTAGONISTS | SCHERING CORP (US) | 2008-10-22 | — | — | EP | disclosed |