Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14042574 | 0.85 | LMNA (0.46) | NISCHLMNAADRA2BADRA2CADRA2A | |
| SCHEMBL14042624 | 0.83 | NISCH (0.45) | NISCHLMNAADRA2BADRA2CADRA2A | |
| SCHEMBL14042628 | 0.82 | NISCH (0.50) | NISCHLMNAADRA2BADRA2CADRA2A | |
| SCHEMBL949042 | 0.82 | KDM4E (0.52) | NISCHLMNAADRA2BADRA2CADRA2A | |
| SCHEMBL4785397 | 0.82 | PTGIR (0.47) | NISCHLMNAADRA2BADRA2CADRA2A | |
| SCHEMBL14042632 | 0.81 | LMNA (0.44) | NISCHLMNAADRA2BADRA2CADRA2A | |
| SCHEMBL4788507 | 0.81 | SLC6A2 (0.46) | NISCHLMNAADRA2BADRA2CADRA2A | |
| SCHEMBL14042630 | 0.81 | CYP2D6 (0.46) | NISCHADRA2BADRA2CADRA2AADRA1D | |
| Iodide SCHEMBL951481 | 0.81 | KDM4E (0.51) | NISCHLMNAADRA2BADRA2CADRA2A | |
| SCHEMBL4788615 | 0.80 | PTGIR (0.44) | NISCHLMNAADRA2BADRA2CADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123821-A1 | 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-10-16 | — | — | WO | disclosed |