Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NISCH | Q9Y2I1 | 8/20 | 0.48 |
| ▸ | MAOA | P21397 | 7/20 | 0.48 |
| ▸ | MAOB | P27338 | 7/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL949042 | 0.99 | KDM4E (0.52) | KDM4EHTTNPSR1L3MBTL1CYP1A2 | |
| SCHEMBL4788335 | 0.92 | CYP1A2 (0.48) | KDM4EHTTNPSR1L3MBTL1CYP1A2 | |
| SCHEMBL4788401 | 0.89 | KDM4E (0.44) | KDM4EHTTNPSR1L3MBTL1CYP1A2 | |
| SCHEMBL4788615 | 0.89 | PTGIR (0.44) | KDM4EHTTNPSR1L3MBTL1CYP1A2 | |
| SCHEMBL4788602 | 0.89 | NISCH (0.44) | KDM4EHTTNPSR1L3MBTL1CYP1A2 | |
| SCHEMBL4785397 | 0.89 | PTGIR (0.47) | KDM4EHTTNPSR1L3MBTL1CYP1A2 | |
| SCHEMBL12637713 | 0.88 | CYP1A2 (0.58) | KDM4EHTTNPSR1L3MBTL1CYP1A2 | |
| SCHEMBL4787326 | 0.88 | CYP1A2 (0.58) | KDM4EHTTNPSR1L3MBTL1CYP1A2 | |
| Iodide SCHEMBL949559 | 0.88 | WDR5 (0.46) | KDM4EHTTNPSR1L3MBTL1CYP1A2 | |
| SCHEMBL4114349 | 0.86 | WDR5 (0.48) | KDM4EHTTNPSR1L3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7871960-B2 | 1-(Imidazolin-2-yl)amino-1,2-diphenylethane compounds for combating animal pests | BASF SE (DE) | 2011-01-18 | — | — | US | disclosed |
| EP-1888533-B1 | 1-(IMIDAZOLIN-2-YL)AMINO-1,2-DIPHENYLETHANE COMPOUNDS FOR COMBATING ANIMAL PESTS | BASF SE (DE) | 2010-12-15 | — | — | EP | disclosed |
| US-20080200335-A1 | 1-(Imidazolin-2-Yl)Amino-1,2-Diphenylethane Compounds For Combating Animal Pests | BASF AKTIENGESELLSCHAFT (DE) | 2008-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200335-A1 | 1-(Imidazolin-2-Yl)Amino-1,2-Diphenylethane Compounds For Combating Animal Pests | ANXA1, ANXA11, AGO2 | KDM4E 2092/4885HTT 3597/4885NPSR1 2421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.