Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.46 |
| ▸ | NISCH | Q9Y2I1 | 4/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14042574 | 0.84 | LMNA (0.46) | NISCHADRA2AADRA2BADRA2CMAOA | |
| SCHEMBL14042629 | 0.81 | NISCH (0.46) | SLC6A2SLC6A4NISCHADRA2AADRA2B | |
| SCHEMBL14042632 | 0.81 | LMNA (0.44) | NISCHADRA2AADRA2BADRA2CMAOA | |
| SCHEMBL14042628 | 0.80 | NISCH (0.50) | SLC6A2SLC6A4NISCHTAAR1ADRA2A | |
| SCHEMBL949042 | 0.79 | KDM4E (0.52) | NISCHTAAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL14042630 | 0.79 | CYP2D6 (0.46) | SLC6A2SLC6A4NISCHADRA2AADRA2B | |
| Iodide SCHEMBL951481 | 0.78 | KDM4E (0.51) | NISCHTAAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL4788949 | 0.76 | ACP3 (0.45) | SLC6A4NISCHADRA2AMAOAMAOB | |
| SCHEMBL561201 | 0.76 | LMNA (0.56) | SLC6A2SLC6A4NISCHTAAR1ADRA2A | |
| SCHEMBL14042021 | 0.76 | NISCH (0.43) | NISCHADRA2AADRA2BADRA2CMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123821-A1 | 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-10-16 | — | — | WO | claimed |
| WO-2008123821-A1 | 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-10-16 | — | — | WO | disclosed |