Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14043019 | 0.90 | P2RX7 (0.35) | P2RX7SMN1; SMN2 | |
| SCHEMBL2158238 | 0.85 | MAPT (0.50) | MAPTKDM4ENPC1RAB9ACASP3 | |
| SCHEMBL4727903 | 0.82 | MAPT (0.39) | MAPTKDM4ENPC1RAB9ACASP3 | |
| SCHEMBL4733392 | 0.82 | NPC1 (0.42) | MAPTKDM4ENPC1RAB9ACASP3 | |
| SCHEMBL14223515 | 0.81 | MAPT (0.42) | MAPTKDM4ENPC1RAB9ACASP3 | |
| SCHEMBL4147674 | 0.81 | MAPT (0.42) | MAPTKDM4ENPC1RAB9ACASP3 | |
| SCHEMBL4733487 | 0.81 | RAB9A (0.42) | MAPTKDM4ENPC1RAB9ACASP3 | |
| SCHEMBL1961039 | 0.79 | FLT1 (0.39) | MAPTKDM4ENPC1RAB9ACASP3 | |
| SCHEMBL14223297 | 0.79 | MAPT (0.39) | MAPTKDM4ENPC1RAB9ACASP3 | |
| SCHEMBL14223296 | 0.78 | RAB9A (0.39) | MAPTKDM4ENPC1RAB9ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008125599-A1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-23 | — | — | WO | disclosed |