Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4729542 | 0.92 | NPC1 (0.38) | NPC1RAB9AKDM4EMAPTCASP3 | |
| SCHEMBL4727903 | 0.86 | MAPT (0.39) | NPC1RAB9AKDM4EMAPTCASP3 | |
| SCHEMBL14043169 | 0.82 | MAPT (0.44) | NPC1RAB9AKDM4EMAPTCASP3 | |
| SCHEMBL13852137 | 0.80 | PDE4D (0.39) | NPC1RAB9AKDM4EMAPTCASP3 | |
| SCHEMBL4148408 | 0.80 | PDE4D (0.39) | NPC1RAB9AKDM4EMAPTCASP3 | |
| SCHEMBL2158238 | 0.80 | MAPT (0.50) | NPC1RAB9AKDM4EMAPTCASP3 | |
| SCHEMBL4730446 | 0.79 | KDM4E (0.38) | NPC1RAB9AKDM4EMAPTCASP3 | |
| SCHEMBL4733487 | 0.78 | RAB9A (0.42) | NPC1RAB9AKDM4EMAPTCASP3 | |
| SCHEMBL4732771 | 0.78 | APOBEC3A (0.34) | NPC1RAB9AKDM4ESMN1; SMN2PDE4D | |
| SCHEMBL14223515 | 0.77 | MAPT (0.42) | NPC1RAB9AKDM4EMAPTCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |