SCHEMBL1404491

SCHEMBL1404491

O=C(O)Cn1cnc2c(OCc3ccccc3)ncnc21

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAPK1 P53355 3/20 0.72
GALR3 O60755 1/20 0.58
NR2F2 P24468 1/20 0.58
FLT4 P35916 1/20 0.58
KDR P35968 1/20 0.58
SLC29A1 Q99808 1/20 0.50
EGFR P00533 2/20 0.49
HPGD P15428 2/20 0.48
ADORA2A P29274 2/20 0.45
PI4KA P42356 1/20 0.45
PI4K2B Q8TCG2 1/20 0.45
PI4K2A Q9BTU6 1/20 0.45
PI4KB Q9UBF8 1/20 0.45
ALDH1A1 P00352 1/20 0.44
LMNA P02545 1/20 0.44
TSHR P16473 1/20 0.44
MAPK1 P28482 1/20 0.44
HTT P42858 1/20 0.44
PDE4A P27815 1/20 0.43
PDE4B Q07343 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12436865 0.88 DAPK1 (0.66) DAPK1GALR3NR2F2FLT4KDR
SCHEMBL17115735 0.84 DAPK1 (1.00) DAPK1GALR3NR2F2SLC29A1HPGD
SCHEMBL12436866 0.82 DAPK1 (0.55) DAPK1GALR3NR2F2FLT4KDR
SCHEMBL2153643 0.81 MGMT (0.54) DAPK1GALR3NR2F2FLT4KDR
SCHEMBL8769186 0.80 FLT4 (0.72) DAPK1GALR3NR2F2FLT4KDR
SCHEMBL8340777 0.79 DAPK1 (0.46) DAPK1GALR3NR2F2FLT4KDR
SCHEMBL3130095 0.79 TDP1 (0.48) DAPK1FLT4KDREGFRHPGD
SCHEMBL1404487 0.78 DAPK1 (0.58) DAPK1GALR3NR2F2FLT4KDR
SCHEMBL23453027 0.77 HTT (0.51) DAPK1GALR3NR2F2HPGDADORA2A
SCHEMBL6242402 0.77 DAPK1 (0.44) DAPK1GALR3NR2F2FLT4KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10036066-B2 In situ hybridization detection method DAKO DENMARK A/S (DK) 2018-07-31 US disclosed
US-9598720-B2 Monomeric and polymeric linkers useful for conjugating biological molecules and other substances DAKO DENMARK A/S (DK) 2017-03-21 US disclosed
US-20160273035-A1 IN SITU HYBRIDIZATION DETECTION METHOD DAKO DENMARK A/S (DK) 2016-09-22 US disclosed
EP-1919930-B1 NEW NUCLEIC ACID BASE PAIRS DAKO DENMARK AS (DK) 2016-09-14 EP disclosed
US-9340824-B2 Immunohistochemistry detection method DAKO DENMARK A/S (DK) 2016-05-17 US disclosed
US-9017992-B2 In situ hybridization detection method DAKO DENMARK A/S (DK) 2015-04-28 US disclosed
EP-1910575-B1 IMMUNOHISTOCHEMISTRY DETECTION METHOD DAKO DENMARK AS (DK) 2014-12-10 EP disclosed
US-20140315204-A1 Immunohistochemistry Detection Method DAKO DENMARK A/S (DK) 2014-10-23 US disclosed
US-8741566-B2 Immunohistochemistry and in situ hybridization detection method DAKO DENMARK A/S (DK) 2014-06-03 US disclosed
US-20140080145-A1 Monomeric and Polymeric Linkers Useful For Conjugating Biological Molecules and Other Substances DAKO DENMARK A/S (DK) 2014-03-20 US disclosed
EP-1919930-A2 NEW NUCLEIC ACID BASE PAIRS Dako Denmark A/S (DK) 2008-05-14 EP disclosed
EP-1920073-A2 METHOD OF SIMULTANEOUSLY VISUALIZING MULTIPLE BIOLOGICAL TARGETS Dako Denmark A/S (DK) 2008-05-14 EP disclosed
EP-1910575-A2 IMMUNOHISTOCHEMISTRY DETECTION METHOD Dako Denmark A/S (DK) 2008-04-16 EP disclosed
EP-1907592-A2 MONOMERIC AND POLYMERIC LINKERS USEFUL FOR CONJUGATING BIOLOGICAL MOLECULES AND OTHER SUBSTANCES Dako Denmark A/S (DK) 2008-04-09 EP disclosed
WO-2007031874-A9 METHOD OF SIMULTANEOUSLY VISUALIZING MULTIPLE BIOLOGICAL TARGETS DAKO DENMARK AS (DK) 2007-05-31 WO disclosed
WO-2007045998-A2 NEW NUCLEIC ACID BASE PAIRS DAKO DENMARK A/S (US) 2007-04-26 WO disclosed
WO-2007031874-A2 METHOD OF SIMULTANEOUSLY VISUALIZING MULTIPLE BIOLOGICAL TARGETS DAKO DENMARK A/S (US) 2007-03-22 WO disclosed
WO-2007026252-A2 IN SITU HYBRIDIZATION DETECTION METHOD DAKO DENMARK A/S (US) 2007-03-08 WO disclosed
WO-2007023390-A2 IMMUNOHISTOCHEMISTRY DETECTION METHOD DAKO DENMARK A/S (US) 2007-03-01 WO disclosed
WO-2007015168-A2 MONOMERIC AND POLYMERIC LINKERS USEFUL FOR CONJUGATING BIOLOGICAL MOLECULES AND OTHER SUBSTANCES DAKO DENMARK A/S (US) 2007-02-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140080145-A1 Monomeric and Polymeric Linkers Useful For Conjugating Biological Molecules and Other Substances PCNA, DCLRE1A, TK1 DAPK1 2106/4885GALR3 2296/4885NR2F2 4580/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.