Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 7/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24974559 | 0.78 | ESR1 (0.34) | PDE10AALDH1A1HPGDCYP1A2 | |
| Tert-Butylbenzene SCHEMBL27402238 | 0.78 | TP53 (0.38) | KDM4EALDH1A1CYP1A2 | |
| SCHEMBL18177013 | 0.77 | SCN10A (0.39) | SCN10AKCNH2PDE10AMETAP2LCK | |
| SCHEMBL4548606 | 0.77 | SCN10A (0.39) | SCN10AKCNH2PDE10AMETAP2LCK | |
| SCHEMBL13363088 | 0.77 | CYP1A2 (0.46) | KDM4EALDH1A1CYP1A2 | |
| SCHEMBL179533 | 0.76 | LCK (0.52) | SCN10AKCNH2LCKKITSRC | |
| SCHEMBL13273390 | 0.76 | HTR3A (0.48) | PDE10AKDRKDM4EALDH1A1 | |
| SCHEMBL30781766 | 0.76 | NOS1 (0.34) | — | |
| SCHEMBL24204603 | 0.76 | EGFR (0.49) | KCNH2PDE10ALCKKDRKDM4E | |
| SCHEMBL19104136 | 0.76 | ALDH1A1 (0.42) | SCN10AKCNH2PDE10AMETAP2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435823-B2 | Compounds and methods of use | AMGEN INC. (US) | 2008-10-14 | — | — | US | disclosed |