Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | BRAF | P15056 | 11/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1404811 | 0.90 | BRAF (0.38) | BRAFGPR142 | |
| SCHEMBL1384815 | 0.89 | MEN1 (0.38) | MEN1ALDH1A1MAPTKMT2ABRAF | |
| SCHEMBL1404768 | 0.89 | ABL1 (0.38) | ALDH1A1MAPTBRAFGPR142CYP1A2 | |
| SCHEMBL1404789 | 0.88 | LMNA (0.43) | BRAFLMNAGPR142 | |
| SCHEMBL1404669 | 0.88 | BRAF (0.36) | BRAFGPR142 | |
| SCHEMBL1404576 | 0.88 | BRAF (0.39) | MAPTBRAF | |
| SCHEMBL5779078 | 0.87 | BRAF (0.37) | BRAFGPR142 | |
| SCHEMBL1404902 | 0.86 | BRAF (0.36) | BRAFGPR142 | |
| SCHEMBL1404647 | 0.85 | BRAF (0.36) | BRAF | |
| SCHEMBL1404662 | 0.85 | MAPK14 (0.38) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692116-B1 | 1,2,3-TRIAZOLE AMIDE DERIVATIVES AS INHIBITORS OF CYTOKINE PRODUCTION | BOEHRINGER INGELHEIM PHARMA (US) | 2011-03-09 | — | — | EP | claimed |