Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 4/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4663285 | 0.86 | IKBKB (0.47) | PIK3CAPIK3CBPIK3CGPIK3CDHTT | |
| SCHEMBL5009858 | 0.81 | IKBKB (0.40) | PIK3CAPIK3CBPIK3CGPIK3CDCSNK2A1 | |
| SCHEMBL5009877 | 0.80 | HPGDS (0.49) | PKMALDH1A1HTTPARP1TP53 | |
| SCHEMBL14048291 | 0.72 | IKBKB (0.54) | IKBKBCHUK | |
| SCHEMBL4666824 | 0.69 | IKBKB (0.55) | HTTPARP1PARP2KDM4EGLA | |
| SCHEMBL4665025 | 0.69 | IKBKB (0.60) | PIK3CAPIK3CBPIK3CGPIK3CDALDH1A1 | |
| SCHEMBL4664952 | 0.69 | IKBKB (0.51) | PIK3CAPIK3CBPIK3CGPIK3CDHTT | |
| SCHEMBL4664992 | 0.63 | ALDH1A1 (0.41) | ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL4665016 | 0.63 | HTT (0.48) | TDP1ALDH1A1HTTKDM4EGAA | |
| SCHEMBL5007717 | 0.63 | HTT (0.48) | TDP1ALDH1A1HTTPARP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242685-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242685-A1 | Chemical Compounds | NFKBIA, IKBKG, NFKB2 | PIK3CA 319/4885PIK3CB 243/4885PIK3CG 324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.