Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MLYCD | O95822 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TSPO | P30536 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4943847 | 1.00 | LMNA (0.48) | LMNAMCL1DPP4ALDH1A1MMP1 | |
| Hydrochloric Acid SCHEMBL5796983 | 0.98 | LMNA (0.46) | LMNAMCL1DPP4ALDH1A1MMP1 | |
| Nitric Acid SCHEMBL14696458 | 0.88 | LMNA (0.39) | LMNAMCL1DPP4ALDH1A1MEN1 | |
| SCHEMBL30740976 | 0.85 | ALDH1A1 (0.39) | LMNAMCL1DPP4ALDH1A1MMP1 | |
| SCHEMBL1344936 | 0.81 | ALDH1A1 (0.47) | MCL1DPP4ALDH1A1TSHRMAPK1 | |
| SCHEMBL4943840 | 0.80 | DPP4 (0.37) | LMNAMCL1DPP4 | |
| SCHEMBL9653268 | 0.78 | — | — | |
| SCHEMBL1962379 | 0.78 | CA12 (0.47) | MCL1ALDH1A1MMP1MMP2MMP3 | |
| SCHEMBL28722595 | 0.78 | MCL1 (0.38) | MCL1DPP4ALDH1A1MEN1KMT2A | |
| SCHEMBL206810 | 0.77 | LMNA (0.50) | LMNADPP4ALDH1A1MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 269 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118837466-A | Method for measuring residual impurities in entacapone by high performance liquid chromatography | 山东新华制药股份有限公司 | 2024-10-25 | — | — | CN | claimed |
| CN-118287150-A | Method for efficiently catalyzing Knoevenagel condensation reaction by porphyrin and quaternary ammonium salt synergistic catalytic system | 沈阳药科大学 | 2024-07-05 | — | — | CN | claimed |
| US-20240016743-A1 | A METHOD FOR PRODUCING ENTACAPONE TABLETS | CHINA MEHECO KANGLI PHARMA CO., LTD. (CN) | 2024-01-18 | — | — | US | claimed |
| CN-114577927-B | Method for detecting residual impurities in entacapone | 河北广祥制药有限公司 | 2023-09-01 | — | — | CN | claimed |
| CN-116564602-A | Insulating flame-retardant type new energy automobile cable and production process thereof | 广东金牌电缆集团股份有限公司 | 2023-08-08 | — | — | CN | claimed |
| CN-114577927-A | Method for detecting residual impurities in entacapone | 河北广祥制药有限公司 | 2022-06-03 | — | — | CN | claimed |
| CN-114276605-A | High-temperature-resistant halogen-free flame-retardant cable and preparation process thereof | 温州网牌电线电缆有限公司 | 2022-04-05 | — | — | CN | claimed |
| CN-107017434-B | Nonaqueous electrolytic solution and lithium ion secondary battery | 宁德新能源科技有限公司 | 2019-06-11 | — | — | CN | claimed |
| CN-109286041-A | Electrolyte and secondary lithium battery | 宁德时代新能源科技股份有限公司 | 2019-01-29 | — | — | CN | claimed |
| CN-107017434-A | Nonaqueous electrolytic solution and lithium rechargeable battery | 宁德新能源科技有限公司 | 2017-08-04 | — | — | CN | claimed |
| EP-1701936-A4 | AN EFFICIENT PROCESS FOR THE MANUFACTURE OF (E)-ENTACAPONE POLYMORPHIC FORM A | WOCKHARDT LTD (IN) | 2007-01-24 | — | — | EP | claimed |
| US-20060258877-A1 | Process for the preparation of (E)-2-cyano-3-(3, 4-dihydroxy-5-nitrophenyl)-N, N-diethyl-2-propenamide (entacapone) | ALEMBIC LIMITED (IN) | 2006-11-16 | — | — | US | claimed |
| EP-1713768-A2 | NOVEL CRYSTALLINE FORMS OF ENTACAPONE AND PRODUCTION THEREOF | Cilag AG (CH) | 2006-10-25 | — | — | EP | claimed |
| EP-1701936-A1 | AN EFFICIENT PROCESS FOR THE MANUFACTURE OF (E)-ENTACAPONE POLYMORPHIC FORM A | Wockhardt Limited (IN) | 2006-09-20 | — | — | EP | claimed |
| EP-1701937-A1 | STABLE POLYMORPHS OF (E)-N,N-DIETHYL-2-CYANO-3-(3,4-DIHYDROXY-5-NITROPHENYL)ACRYLAMIDE | Wockhardt Limited (IN) | 2006-09-20 | — | — | EP | claimed |
| WO-2006064296-A1 | PROCESS FOR THE PREPARATION OF (E)-N,N-DIETHYL-2-CYANO-3(3,4-DIHYDROXY-5-NITRO-PHENYL)-ACRYLAMIDE IN STABLE POLYMORPHIC FORM AND INTERMEDIATES OF THE PROCESS | ALKALOIDA KUTATO ES FEJLESZTÖ KFT (HU) | 2006-06-22 | — | — | WO | claimed |
| WO-2005070881-A1 | AN EFFICIENT PROCESS FOR THE MANUFACTURE OF (E)-ENTACAPONE POLYMORPHIC FORM A | WOCKHARDT LIMITED (IN) | 2005-08-04 | — | — | WO | claimed |
| WO-2005066117-A1 | STABLE POLYMORPHS OF (E)-N,N-DIETHYL-2-CYANO-3-(3,4-DIHYDROXY-5-NITROPHENYL)ACRYLAMIDE | WOCKHARDT LIMITED (IN) | 2005-07-21 | — | — | WO | claimed |
| WO-2005063696-A2 | NOVEL CRYSTALLINE FORMS OF ENTACAPONE AND PRODUCTION THEREOF | CILAG AG (CH) | 2005-07-14 | — | — | WO | claimed |
| WO-2005063695-A1 | NOVEL CRYSTALLINE FORMS OF ENTACAPONE, AND PRODUCTION THEREOF | CILAG AG (CH) | 2005-07-14 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060258877-A1 | Process for the preparation of (E)-2-cyano-3-(3, 4-dihydroxy-5-nitrophenyl)-N, N-diethyl-2-propenamide (entacapone) | GNE, DDT, NME2 | LMNA 319/4885MCL1 4300/4885DPP4 595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.