Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | HTR2A | P28223 | 1/20 | 0.67 |
| ▸ | SCN1A | P35498 | 1/20 | 0.67 |
| ▸ | HTR2B | P41595 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.67 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | HRH2 | P25021 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | LTA4H | P09960 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5738766 | 0.93 | LTA4H (0.66) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL4730254 | 0.84 | HRH3 (0.68) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL28636689 | 0.82 | HRH3 (0.73) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL13186317 | 0.82 | HRH3 (0.80) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL8795711 | 0.82 | HRH3 (0.70) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL21757567 | 0.81 | HRH3 (0.63) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 | |
| Pramoxine SCHEMBL26020 | 0.80 | ALDH1A1 (1.00) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL23963137 | 0.80 | HRH3 (0.67) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL21119254 | 0.80 | LTA4H (0.64) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL17296202 | 0.80 | HRH3 (0.62) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012162461-A1 | PHENYL-THIAZOLYL INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION | JANSSEN PHARMACEUTICA NV (BE) | 2012-11-29 | — | — | WO | disclosed |