Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.37 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 3/20 | 0.30 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14059413 | 0.87 | LRRK2 (0.46) | LRRK2KMT5APDE10AEGFR | |
| SCHEMBL14059572 | 0.87 | LRRK2 (0.49) | LRRK2KMT5APDE10A | |
| SCHEMBL14060106 | 0.84 | LRRK2 (0.45) | LRRK2 | |
| SCHEMBL14059459 | 0.84 | LRRK2 (0.53) | LRRK2 | |
| SCHEMBL14059181 | 0.82 | LRRK2 (0.46) | LRRK2ERBB2 | |
| SCHEMBL14059477 | 0.81 | LRRK2 (0.46) | LRRK2TSHRMAPK1 | |
| SCHEMBL14059347 | 0.77 | LRRK2 (0.52) | LRRK2 | |
| SCHEMBL14059211 | 0.76 | LRRK2 (0.52) | LRRK2KMT5APDE10AMAPK1SMN1; SMN2 | |
| SCHEMBL14059970 | 0.76 | LRRK2 (0.54) | LRRK2 | |
| SCHEMBL14062308 | 0.75 | LRRK2 (0.55) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726465-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | Elan Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | disclosed |
| WO-2012162254-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2012-11-29 | — | — | WO | disclosed |