Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | RAD52 | P43351 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.47 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL201860 | 0.81 | CA1 (0.61) | ALDH1A1HPGDRAD52PRSS1PRSS2 | |
| SCHEMBL9702109 | 0.81 | KDM4E (0.70) | KDM4EALDH1A1HPGDCYP1A2CYP2A6 | |
| SCHEMBL3368290 | 0.81 | PRSS1 (0.68) | KDM4EALDH1A1HPGDCYP1A2CYP2A6 | |
| SCHEMBL31546801 | 0.81 | PRSS1 (0.68) | KDM4EALDH1A1HPGDCYP1A2CYP2A6 | |
| Hydrochloric Acid SCHEMBL31546705 | 0.79 | PRSS1 (0.66) | KDM4EPRSS1PRSS2PRSS3PLAU | |
| SCHEMBL29500266 | 0.78 | PARP1 (0.67) | ALDH1A1HPGDRAD52PRSS1PRSS2 | |
| SCHEMBL2888543 | 0.78 | PARP1 (0.67) | ALDH1A1HPGDRAD52PRSS1PRSS2 | |
| SCHEMBL23864974 | 0.78 | KDM4E (0.56) | KDM4EALDH1A1HPGDCYP1A2CYP2A6 | |
| SCHEMBL11810869 | 0.76 | KDM4E (0.75) | KDM4EALDH1A1HPGDCYP1A2CYP2A6 | |
| SCHEMBL17288621 | 0.76 | KDM4E (0.63) | KDM4EALDH1A1HPGDCYP1A2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2714682-B1 | NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS FOR USE IN THE DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES | UNIVERSITÀ DEGLI STUDI DI BARI ALDO MORO (IT) | 2016-03-16 | — | — | EP | disclosed |
| US-9095631-B2 | Tetrahydroisoquinoline compounds for use in the diagnosis and treatment of neurodegenerative diseases | UNIVERSITA DEGLI STUDI DI BARI “ALDO MORO” (IT) | 2015-08-04 | — | — | US | disclosed |
| US-9095631-B2 | Tetrahydroisoquinoline compounds for use in the diagnosis and treatment of neurodegenerative diseases | UNIVERSITA DEGLI STUDI DI BARI “ALDO MORO” (IT) | 2015-08-04 | — | — | US | disclosed |
| US-9095631-B2 | Tetrahydroisoquinoline compounds for use in the diagnosis and treatment of neurodegenerative diseases | UNIVERSITA DEGLI STUDI DI BARI “ALDO MORO” (IT) | 2015-08-04 | — | — | US | disclosed |
| US-20140112868-A1 | NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS FOR USE IN THE DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES | UNIVERSITA' DEGLI STUDI DI BARI "ALDO MORO" (IT) | 2014-04-24 | — | — | US | disclosed |
| WO-2012159666-A1 | NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS FOR USE IN THE DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES | UNIVERSITA' DEGLI STUDI DI BARI (IT) | 2012-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140112868-A1 | NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS FOR USE IN THE DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES | ABCB1, ABCG2, ABCC2 | KDM4E 4182/4885ALDH1A1 1718/4885HPGD 431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.