Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 3/20 | 0.68 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.68 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.68 |
| ▸ | PLAU | P00749 | 6/20 | 0.60 |
| ▸ | PLG | P00747 | 3/20 | 0.60 |
| ▸ | KLK1 | P06870 | 2/20 | 0.60 |
| ▸ | F2 | P00734 | 1/20 | 0.60 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | F12 | P00748 | 3/20 | 0.58 |
| ▸ | PTGIR | P43119 | 1/20 | 0.56 |
| ▸ | F10 | P00742 | 1/20 | 0.54 |
| ▸ | PLAT | P00750 | 1/20 | 0.51 |
| ▸ | NQO2 | P16083 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31546801 | 1.00 | PRSS1 (0.68) | PRSS1PRSS2PRSS3PLAUPLG | |
| Hydrochloric Acid SCHEMBL31546705 | 0.98 | PRSS1 (0.66) | PRSS1PRSS2PRSS3PLAUPLG | |
| SCHEMBL428892 | 0.81 | PRSS1 (1.00) | PRSS1PRSS2PRSS3PLAUF2 | |
| SCHEMBL19478949 | 0.81 | PLAU (0.60) | PRSS1PRSS2PRSS3PLAUPLG | |
| SCHEMBL14060422 | 0.81 | KDM4E (0.59) | PRSS1PRSS2PRSS3PLAUKDM4E | |
| SCHEMBL9702109 | 0.81 | KDM4E (0.70) | PLAUPLGKDM4EPLATCYP1A2 | |
| Hydrochloric Acid SCHEMBL2570665 | 0.79 | PRSS1 (0.95) | PRSS1PRSS2PRSS3PLAUF2 | |
| SCHEMBL18639608 | 0.79 | KDM4E (0.58) | PRSS1PRSS2PRSS3PLAUPLG | |
| SCHEMBL10938112 | 0.79 | F12 (0.59) | PRSS1PLAUPLGKLK1F2 | |
| SCHEMBL30071591 | 0.79 | PLAU (0.57) | PLAUPLGF2KDM4EF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476435-B1 | NOVEL PYRIDIN- AND PYRIMIDIN-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-06-30 | — | — | EP | disclosed |
| US-7022718-B2 | Pyridine and pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-04-04 | — | — | US | disclosed |
| US-20050143405-A1 | Pyridine and pyrimidine derivatives | BOEHRINGER MARKUS (CH) | 2005-06-30 | — | — | US | disclosed |
| US-6867205-B2 | Pyridine and pyrimidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2005-03-15 | — | — | US | disclosed |
| EP-1476435-A1 | NOVEL PYRIDIN- AND PYRIMIDIN-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003068757-A9 | NOVEL PYRIDIN- AND PYRIMIDIN-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2004-10-07 | — | — | WO | disclosed |
| US-20030216382-A1 | Pyridine and pyrimidine derivatives | HOFFMAN-LA ROCHE INC. | 2003-11-20 | — | — | US | disclosed |
| WO-2003068757-A1 | NOVEL PYRIDIN- AND PYRIMIDIN-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216382-A1 | Pyridine and pyrimidine derivatives | DPP4, GPR119, G6PC1 | PRSS1 283/4885PRSS2 1024/4885PRSS3 555/4885 |
| US-20050143405-A1 | Pyridine and pyrimidine derivatives | DPP4, GPR119, PDXK | PRSS1 217/4885PRSS2 895/4885PRSS3 372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.