Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28196747 | 0.77 | CHRM2 (0.41) | CHRM2CHRM1LTA4HPTGS2KDM4E | |
| SCHEMBL6988370 | 0.74 | TDP1 (0.56) | TDP1TSHRALDH1A1TP53HIF1A | |
| SCHEMBL6988371 | 0.74 | TDP1 (0.56) | TDP1TSHRALDH1A1TP53HIF1A | |
| SCHEMBL31677377 | 0.74 | TDP1 (0.56) | TDP1TSHRALDH1A1TP53HIF1A | |
| SCHEMBL30338856 | 0.74 | KDM4C (0.42) | LMNACHRM2CHRM1LTA4HPTGS2 | |
| SCHEMBL14060660 | 0.73 | TDP1 (0.46) | TDP1TSHRALDH1A1TP53HIF1A | |
| SCHEMBL18919007 | 0.71 | ALDH1A1 (0.61) | TDP1TSHRALDH1A1TP53HIF1A | |
| SCHEMBL31508228 | 0.71 | CHRM2 (0.35) | SMN1; SMN2BACE1CHRM2CHRM1LTA4H | |
| SCHEMBL8436789 | 0.71 | CHRNA3 (0.58) | CYP1A2KDM4E | |
| SCHEMBL7374644 | 0.71 | CHRNA3 (0.58) | CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9260400-B2 | I-arylpiperazinic ligands of 5-HT7 receptor and use thereof | UNIVERSITA' DEGLI STUDI DI BARI “ALDO MORO” (IT) | 2016-02-16 | — | — | US | disclosed |
| EP-2816037-A2 | New 1-arylpiperazinic ligands of 5-HT7 receptor and use thereof | Università degli Studi di Bari "Aldo Moro" (IT) | 2014-12-24 | — | — | EP | disclosed |
| US-20140086834-A1 | NEW I-ARYLPIPERAZINIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF | UNIVERSITA' DEGLI STUDI DI BARI ''ALDO MORO'' (IT) | 2014-03-27 | — | — | US | disclosed |
| WO-2012159662-A1 | NEW 1-ARYLPIPERAZINIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF | UNIVERSITA' DEGLI STUDI DI BARI (IT) | 2012-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140086834-A1 | NEW I-ARYLPIPERAZINIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF | HTR7, HTR2C, HTR5A | TDP1 3809/4885TSHR 205/4885ALDH1A1 1787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.