Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 7/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR5A | P47898 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27953728 | 0.87 | ADRB1 (0.46) | ADRB1HTR7HTR1AHTR6HTR2A | |
| SCHEMBL27943377 | 0.81 | ADRB1 (0.51) | ADRB1HTR7HTR1AHTR6HTR2A | |
| SCHEMBL27774299 | 0.69 | ADRB1 (0.46) | ADRB1HTR7HTR1AHTR6HTR2A | |
| SCHEMBL27953737 | 0.68 | ADRB1 (0.49) | ADRB1HTR7HTR1AHTR6HTR2A | |
| SCHEMBL27953748 | 0.68 | CYP1A2 (0.46) | CYP1A2CYP3A4CYP2C19LMNACLK4 | |
| SCHEMBL29446047 | 0.68 | ADRB1 (1.00) | ADRB1HTR7HTR1AHTR6HTR2A | |
| SCHEMBL5785574 | 0.68 | ADRB1 (1.00) | ADRB1HTR7HTR1AHTR6HTR2A | |
| SCHEMBL230424 | 0.68 | ADRB1 (1.00) | ADRB1HTR7HTR1AHTR6HTR2A | |
| SCHEMBL13118662 | 0.67 | HTR7 (0.69) | ADRB1HTR7HTR1AHTR6HTR2A | |
| SCHEMBL5566823 | 0.67 | HTR7 (0.63) | ADRB1HTR7HTR1AHTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | claimed |
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | disclosed |
| EP-2681221-A1 | TRICYCLIC INHIBITORS OF KINASES | AbbVie Inc. (US) | 2014-01-08 | — | — | EP | disclosed |
| WO-2012161812-A1 | TRICYCLIC INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2012-11-29 | — | — | WO | disclosed |