Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27943377 | 0.86 | ADRB1 (0.51) | CYP1A2CYP2C19CYP3A4CYP2D6HSD17B10 | |
| SCHEMBL14060737 | 0.84 | CYP1A2 (0.43) | CYP1A2CYP2C19CYP3A4CYP2D6HSD17B10 | |
| SCHEMBL27953744 | 0.77 | CYP1A2 (0.48) | CYP1A2CYP2C19CYP3A4CYP2D6HSD17B10 | |
| SCHEMBL14059902 | 0.76 | CYP1A2 (0.47) | CYP1A2CYP2C19CYP3A4CYP2D6HSD17B10 | |
| SCHEMBL27953737 | 0.71 | ADRB1 (0.49) | CYP1A2CYP2C19CYP3A4CYP2D6DRD2 | |
| SCHEMBL424507 | 0.71 | DRD2 (0.75) | LMNAMAPK1ALDH1A1DRD2DRD3 | |
| SCHEMBL27943403 | 0.69 | DRD2 (0.47) | LMNAALDH1A1DRD2DRD3HRH4 | |
| SCHEMBL28028575 | 0.68 | DRD2 (0.46) | CYP2D6ALDH1A1DRD2DRD3MAPT | |
| SCHEMBL6885430 | 0.68 | CYP1A2 (0.57) | CYP1A2CYP2C19CYP3A4CYP2D6HSD17B10 | |
| SCHEMBL14060901 | 0.68 | ADRB1 (0.48) | CYP1A2CYP2C19CYP3A4CYP2D6HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | claimed |
| CN-103703005-A | Tricyclic inhibitors of kinases | ABBOTT LAB | 2014-04-02 | — | — | CN | disclosed |