SCHEMBL14062437

SCHEMBL14062437

COc1ccc([Si](CCCc2ccc(C)cc2)(C(C)C)C(C)C)cc1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CALM1 P0DP23 1/20 0.47
MAPT P10636 2/20 0.46
ALDH1A1 P00352 6/20 0.43
POLB P06746 1/20 0.43
ACHE P22303 1/20 0.43
LMNA P02545 2/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
TDP1 Q9NUW8 1/20 0.42
KMT2A Q03164 3/20 0.40
SIGMAR1 Q99720 1/20 0.40
IGF1R P08069 1/20 0.40
ALOX15 P16050 1/20 0.40
TAAR1 Q96RJ0 1/20 0.40
MEN1 O00255 2/20 0.40
GAA P10253 1/20 0.39
HPGD P15428 1/20 0.39
ALOX12 P18054 1/20 0.39
MAPK1 P28482 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12418040 0.79 HDAC3 (0.39) CALM1MAPTALDH1A1LMNAL3MBTL1
SCHEMBL18857088 0.78 ACHE (0.65) CALM1MAPTALDH1A1ACHELMNA
SCHEMBL13566212 0.75 CA12 (0.41) MAPTALDH1A1LMNAGAA
SCHEMBL13038170 0.74 ACHE (0.71) CALM1MAPTACHELMNAL3MBTL1
SCHEMBL421851 0.73 CA12 (0.39) ALDH1A1LMNAALOX15GAAALOX12
SCHEMBL5361401 0.71 CYP1A2 (0.43) CALM1MAPTALDH1A1ACHEKMT2A
SCHEMBL1585117 0.71 CALM1 (0.58) CALM1ALDH1A1POLBSIGMAR1IGF1R
SCHEMBL17789578 0.71 CA12 (0.44) ALDH1A1ACHEKMT2AMEN1
SCHEMBL23350250 0.71 SIGMAR1 (0.48) CALM1MAPTALDH1A1ACHELMNA
SCHEMBL244070 0.70 CALM1 (0.79) CALM1L3MBTL1TDP1SIGMAR1IGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080221303-A1 Method for the Preparation of Peptide-Oligonucleotide Conjugates FRUTAROM LTD. (IL) 2008-09-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080221303-A1 Method for the Preparation of Peptide-Oligonucleotide Conjugates VIP, PTMS, SSTR4 CALM1 4682/4885MAPT 3340/4885ALDH1A1 4552/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.