Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 18/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1406171 | 0.89 | HTR1A (0.47) | HTR1A | |
| SCHEMBL1322830 | 0.89 | HTR1A (0.55) | HTR1APARP1TNK2TNK1 | |
| SCHEMBL1406250 | 0.83 | HTR1A (0.46) | HTR1A | |
| SCHEMBL6919552 | 0.83 | HTR1A (0.70) | HTR1A | |
| SCHEMBL1322976 | 0.83 | HTR1A (0.51) | HTR1A | |
| SCHEMBL1323788 | 0.76 | HTR1A (0.41) | HTR1A | |
| SCHEMBL7160095 | 0.74 | HTR1A (0.63) | HTR1A | |
| SCHEMBL13633559 | 0.72 | ADRA2A (0.48) | HTR1A | |
| SCHEMBL13638611 | 0.72 | HTR1A (0.49) | HTR1A | |
| SCHEMBL6919604 | 0.72 | HTR1A (0.67) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497279-B1 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GMBH (DE) | 2011-03-09 | — | — | EP | claimed |
| JP-2005523310-A | — | — | 2005-08-04 | — | — | JP | claimed |
| EP-1497279-A2 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GmbH (DE) | 2005-01-19 | — | — | EP | claimed |
| WO-2003087086-A2 | SUBSTITUTED INDOLES | MERCK PATENT GMBH (DE) | 2003-10-23 | — | — | WO | claimed |
| EP-1497279-B1 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GMBH (DE) | 2011-03-09 | — | — | EP | disclosed |