Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 13/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1322976 | 0.89 | HTR1A (0.51) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL1406250 | 0.81 | HTR1A (0.46) | HTR1A | |
| SCHEMBL13638413 | 0.80 | HTR2A (0.41) | HTR1A | |
| SCHEMBL1406171 | 0.77 | HTR1A (0.47) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL1322830 | 0.77 | HTR1A (0.55) | HTR1A | |
| SCHEMBL12123757 | 0.76 | HTR1A (0.67) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL13763299 | 0.75 | HTR1D (0.57) | HTR1A | |
| SCHEMBL1406244 | 0.72 | HTR1A (0.50) | HTR1A | |
| SCHEMBL13955054 | 0.71 | HTR7 (0.54) | HTR1A | |
| SCHEMBL12123965 | 0.71 | HTR1A (0.58) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291963-A1 | SUBSTITUTED INDOLES | SCHADT OLIVER | 2009-11-26 | — | — | US | disclosed |
| US-20090054459-A1 | Substituted indoles | SCHADT OLIVER | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054459-A1 | Substituted indoles | TPH2, TPH1, HTR1A | HTR1A 3/4885ADRA2A 28/4885ADRA2B 54/4885 |
| US-20090291963-A1 | SUBSTITUTED INDOLES | TPH2, TPH1, HTR1A | HTR1A 3/4885ADRA2A 30/4885ADRA2B 55/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.