Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.53 |
| ▸ | NOS1 | P29475 | 1/20 | 0.53 |
| ▸ | NOS2 | P35228 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | F11 | P03951 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.38 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901375 | 0.80 | MEN1 (0.60) | MEN1KMT2AADORA2AADORA1BACE1 | |
| SCHEMBL19531875 | 0.79 | ADORA2A (0.46) | NOS3NOS1NOS2MEN1KMT2A | |
| SCHEMBL21160332 | 0.79 | MEN1 (0.49) | MEN1KMT2AADORA2AADORA1HPGD | |
| SCHEMBL24795567 | 0.78 | MEN1 (0.51) | MEN1KMT2AADORA2AADORA1HPGD | |
| SCHEMBL14063571 | 0.78 | LMNA (0.44) | MEN1KMT2AADORA2AADORA1F11 | |
| SCHEMBL14063562 | 0.75 | ALDH1A1 (0.46) | MEN1KMT2AF11LMNATP53 | |
| SCHEMBL4804130 | 0.75 | F11 (0.48) | MEN1KMT2AADORA2AADORA1F11 | |
| SCHEMBL14072797 | 0.75 | MEN1 (0.61) | NOS3NOS1NOS2MEN1KMT2A | |
| SCHEMBL23113675 | 0.73 | ADORA2A (0.50) | MEN1KMT2AADORA2AADORA1LMNA | |
| SCHEMBL4257749 | 0.72 | MEN1 (0.79) | MEN1KMT2AADORA2AADORA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429604-B2 | Six-membered heterocycles useful as serine protease inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2008-09-30 | — | — | US | disclosed |